Published online Jul 15, 2020. doi: 10.4251/wjgo.v12.i7.705
Peer-review started: December 31, 2019
First decision: May 5, 2020
Revised: May 17, 2020
Accepted: June 17, 2020
Article in press: June 17, 2020
Published online: July 15, 2020
Core tip: The major change in the 2017 World Health Organization (WHO) classification of pancreatic neuroendocrine neoplasms was to further subclassified the original G3 group into pancreatic neuroendocrine tumors G3 (pNETs G3) and pancreatic neuroendocrine carcinoma (pNEC). In 2019 this major change subsequently extended to neuroendocrine neoplasms involving the entire digestive tract. This review comprehensively summarizes the differences between pNET G3 and pNEC, which is the major update in latest WHO grading classification for pancreatic neuroendocrine neoplasms by the aspects of histology, gene mutation, and clinical management.