Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2020; 12(3): 289-300
Published online Mar 15, 2020. doi: 10.4251/wjgo.v12.i3.289
Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population
Xiao-Qin Wang, Yang Li, Paul D Terry, Wen-Jing Kou, Yue Zhang, Zhao-Zhao Hui, Xiao-Han Ren, Ming-Xu Wang
Xiao-Qin Wang, Yang Li, Wen-Jing Kou, Yue Zhang, Xiao-Han Ren, Ming-Xu Wang, Department of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, Shaanxi Province, China
Paul D Terry, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN 37920, United States
Zhao-Zhao Hui, The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China
Author contributions: Wang XQ wrote the manuscript; Wang XQ and Li Y analyzed the data; Li Y, Kou WJ, Zhang Y, Hui ZZ, and Ren XH performed the majority of the experiments; Wang XQ and Wang MX designed the research; Wang MX and Terry PD revised the manuscript.
Supported by the Fundamental Research Funds for the Central Universities, No. zdyf2017007; Project of Shaanxi Health and Culture Research Center, No. JKWH2019-Z02.
Institutional review board statement: This study was approved by the Institutional Review Board of Health Science Center of Xi’an Jiaotong University.
Informed consent statement: Informed consent was obtained from all study participants.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mingxu Wang, PhD, Professor, Department of Public Health, Xi’an Jiaotong University Health Science Center, 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. wangmx601@mail.xjtu.edu.cn
Received: September 6, 2019
Peer-review started: September 6, 2019
First decision: October 14, 2019
Revised: November 18, 2019
Accepted: January 6, 2020
Article in press: January 6, 2020
Published online: March 15, 2020
Core Tip

Core tip: This study investigated the associations between single nucleotide polymorphisms of interleukin-21 (IL-21) gene (rs907715, rs2221903 and rs12508721) and gastric precancerous lesions in a Chinese population. The results showed an association between IL-21 rs907715 polymorphism and gastric precancerous lesions. IL-21 rs907715 genotype CC and C frequencies were higher in patients with gastric precancerous lesions than in the controls. Single nucleotide polymorphism rs907715 increased in CC and C genotypes were associated with intestinal metaplasia patients when examined separately. These findings may help clarify the etiology of gastric cancer.