Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2020; 12(12): 1394-1406
Published online Dec 15, 2020. doi: 10.4251/wjgo.v12.i12.1394
Comparison of survival between adolescent and young adult vs older patients with hepatocellular carcinoma
Jie Ren, Ying-Mu Tong, Rui-Xia Cui, Zi Wang, Qing-Lin Li, Wei Liu, Kai Qu, Jing-Yao Zhang, Chang Liu, Yong Wan
Jie Ren, Ying-Mu Tong, Rui-Xia Cui, Zi Wang, Qing-Lin Li, Wei Liu, Kai Qu, Jing-Yao Zhang, Chang Liu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Jing-Yao Zhang, Chang Liu, Department of SICU, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yong Wan, Department of Geriatric Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Ren J, Tong YM, and Cui RX contributed equally to this work; Ren J participated in the research design, data analysis, and writing of the paper; Tong YM and Cui RX participated in the data analysis; Wang Z, Liu W, and Li QL participated in revising of the paper; Qu K participated in research design and revising of the paper; Zhang JY, Liu C, and Wan Y provided substantial advice in designing the study, assisting in the division of labor, and writing and revising the paper; all authors have read and approved the final manuscript.
Institutional review board statement: The IRB has reviewed this information and found that this protocol does not fall under the purview of the IRB as it does not meet the definition of human subject research.
Informed consent statement: As the data used was accessed via a public national database with deidentified patients, there was no need for informed consent.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Data sharing statement: Data from this manuscript will be available upon request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Wan, MD, Chief Physician, Department of Geriatric Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. rareyong@qq.com
Received: August 31, 2020
Peer-review started: August 31, 2020
First decision: September 12, 2020
Revised: September 20, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: December 15, 2020
Core Tip

Core Tip: Adolescent and young adult (AYA) population refer to people aged 15-39 years old in the United States, and AYA has become a special age phase in oncology research in recent years. We aimed to investigate overall survival (OS) of AYA and older hepatocellular carcinoma patients. Our study confirmed that in different American Joint Committee on Cancer (AJCC) stages, the two groups of patients had different OS: In the AJCC I/II group, advanced age was a risk factor for OS, but it was not a risk factor for OS in the AJCC III/IV group.