Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2019; 11(8): 642-651
Published online Aug 15, 2019. doi: 10.4251/wjgo.v11.i8.642
Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer
Shan Gao, Guo-Hui Cao, Peng Ding, Yang-Yang Zhao, Peng Deng, Bin Hou, Kai Li, Xiao-Fang Liu
Shan Gao, Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Guo-Hui Cao, The first department of oncology, Hebei general Hospital, Shijiazhuang, Hebei Province 050051, China
Peng Ding, Peng Deng, Bin Hou, Kai Li, Xiao-Fang Liu, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Yang-Yang Zhao, School of Public Health, China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Gao S, Zhao YY and Deng P collected the data and drafted the manuscript; Cao GH, Ding P and Hou B analyzed the data; Liu XF and Li K designed and supervised the study.
Supported by the Foundation of Innovative Talents in Higher Education of Liaoning Province, No. LR2016043.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of China Medical University.
Informed consent statement: Patients were not required to give informed consent as the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by providing written consent.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Fang Liu, MD, PhD, Doctor, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. liuxf777@hotmail.com
Telephone: +86-24-83282821
Received: May 21, 2019
Peer-review started: May 21, 2019
First decision: July 16, 2019
Revised: July 18, 2019
Accepted: August 3, 2019
Article in press: August 3, 2019
Published online: August 15, 2019
Core Tip

Core tip: In this study, we found that lymphatic and/or blood vessel invasion (LBVI) + status was associated with Borrmann type IV, low histological grade, large tumor size, and advanced pT and pN status. The 5-year survival rate of LBVI+ patients was significantly lower than that of LBVI– patients. No significant difference was observed in the prognosis of Borrmann type III/LBVI+ disease and Borrmann type IV disease. Therefore, we proposed a revised Borrmann type IV (r-Bor IV) as Borrmann type III plus LBVI+, and found that r-Bor IV was associated with poor prognosis in patients with advanced proximal gastric cancer, which outweighed the prognostic significance of pT status.