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Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2019; 11(7): 518-526
Published online Jul 15, 2019. doi: 10.4251/wjgo.v11.i7.518
Recent progress of chemotherapy and biomarkers for gastroesophageal cancer
Osamu Maeda, Yuichi Ando
Osamu Maeda, Yuichi Ando, Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya 466-8560, Japan
Author contributions: Maeda O wrote the manuscript; Ando Y supervised the review; and all authors read and approved the final manuscript.
Conflict-of-interest statement: No potential conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Osamu Maeda, MD, PhD, Lecturer, Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan. maeda-o@med.nagoya-u.ac.jp
Telephone: +81-52-7441903 Fax: +81-52-7441903
Received: February 20, 2019
Peer-review started: February 22, 2019
First decision: April 16, 2019
Revised: April 17, 2019
Accepted: May 28, 2019
Article in press: May 29, 2019
Published online: July 15, 2019
Core Tip

Core tip: This article reviewed the current status and recent developments of gastroesophageal cancer and its related biomarkers for treatment selection. Platinum, fluoropyrimidines, taxanes, irinotecan, trastuzumab and ramucirumab are key drugs. Recently, anti-PD-1 antibodies have become available. PD-L1 expression and microsatellite instability are used to predict the effectiveness of immunotherapy. Genome-wide analysis will provide a better understanding of the biology in gastroesophageal cancer.