Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2019; 11(2): 172-180
Published online Feb 15, 2019. doi: 10.4251/wjgo.v11.i2.172
Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome: Two case reports and review of literature
Santosh Shenoy, Murali Nittala, Yazen Assaf
Santosh Shenoy, Murali Nittala, Yazen Assaf, Department of General and Colorectal Surgery, KCVA and University of Missouri at Kansas City, Kansas City, MO 64128, United States
Author contributions: Shenoy S designed and drafted the report with other authors as listed analyzed the data and manuscript.
Informed consent statement: Consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the guidelines from the check list have been adopted in the preparation of this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Santosh Shenoy, MD, Surgeon, Department of General and Colorectal Surgery, KCVA and University of Missouri at Kansas City, 4801 E Linwood Blvd., Kansas city, MO 64128, United States.
Telephone: +1-816-8614700 Fax: +1-816-9224609
Received: November 14, 2018
Peer-review started: November 15, 2018
First decision: December 24, 2018
Revised: December 31, 2018
Accepted: January 28, 2019
Article in press: January 28, 2019
Published online: February 15, 2019
Processing time: 93 Days and 8.3 Hours
Core Tip

Core tip: Large anal condylomas are generally caused by low risk human papilloma virus 6, 11, however in certain instances can be caused by high risk subtypes 16, 18, 31, 33. Malignant transformation to squamous cell carcinoma may occur in large neglected tumors and human immunodeficiency virus (HIV) patients. Deep core biopsy, P16 staining and positron emission tomography computed tomography scans are necessary to diagnose carcinoma and metastases. Due to enormous size of the tumors a multidisciplinary team approach is necessary with combination of neoadjuvant chemo radiation followed by wide excision of these tumors. Large perineal and pelvic defects may need pelvic reconstructive surgery. Patients with HIV and anal cancers carry a poor prognosis.