Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2019; 11(12): 1193-1205
Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1193
Multi-parameter ultrasound based on the logistic regression model in the differential diagnosis of hepatocellular adenoma and focal nodular hyperplasia
Meng Wu, Ru-Hai Zhou, Feng Xu, Xian-Peng Li, Ping Zhao, Rui Yuan, Yu-Peng Lan, Wei-Xia Zhou
Meng Wu, Ru-Hai Zhou, Feng Xu, Xian-Peng Li, Ping Zhao, Rui Yuan, Yu-Peng Lan, Wei-Xia Zhou, Department of Ultrasound, Yinzhou Hospital Affiliated to Ningbo University School of Medicine, Ningbo 315000, Zhejiang Province, China
Feng Xu, Xian-Peng Li, Department of Gastroenterology, Yinzhou Hospital Affiliated to Ningbo University School of Medicine, Ningbo 315000, Zhejiang Province, China
Author contributions: Wu M, Zhou RH, Xu F, Li XP, Zhao P and Yuan R designed research; Wu M, Xu F, Zhao P and Lan YP performed research; Lan YP and Zhou WX contributed new analytic tools; Zhou RH, Li XP, Yuan R and Zhou WX analyzed data; and Wu M, Zhou RH, Xu F, Lan YP and Zhou WX wrote the paper.
Supported by Zhejiang Natural Science Foundation, NO. LY16H160004; Ningbo Yinzhou District Agricultural and Social Development Science and Technology Project, NO. Yinke 2018-74.
Institutional review board statement: The study was approved by the ethics committee of Yinzhou Hospital affiliated to Ningbo University School of Medicine.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: None of the authors have any conflict of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Meng Wu, MD, Doctor, Department of Ultrasound, Yinzhou Hospital affiliated to Ningbo University School of Medicine, No. 251 Baizhang East Road, Ningbo 315040, Zhejiang Province, China. wumengcool@sina.com
Telephone: +86-574-87017240
Received: June 15, 2019
Peer-review started: June 18, 2019
First decision: July 31, 2019
Revised: August 13, 2019
Accepted: September 10, 2019
Article in press: September 10, 2019
Published online: December 15, 2019
Core Tip

Core tip: The prognosis of hepatocellular adenoma (HCA) is significantly different from focal nodular hyperplasia (FNH). Accurate identification of HCA and FNH is of great significance. This study explored the accuracy of the combined detection of HCA and FNH by conventional ultrasound, shear wave elastography, and contrast-enhanced ultrasound. The combination of lesion echo, Young’s modulus value and time intense curve decreasing slop in multi-parameter ultrasound index based on logistic regression has high clinical guiding value for the differential diagnosis of HCA and FNH.