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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2019; 11(10): 877-886
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.877
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.877
Fat clearance and conventional fixation identified ypN0 rectal cancers following intermediate neoadjuvant radiotherapy have similar long-term outcomes
Nan Chen, Ting-Ting Sun, Yun-Feng Yao, Lin Wang, Ai-Wen Wu, Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing 100142, China
Zhong-Wu Li, Department of Pathology, Peking University Cancer Hospital, Beijing 100142, China
Author contributions: Chen N, Sun TT, and Li ZW contributed equally to this work; Wang L and Wu AW designed the research; Chen N, Sun TT, Li ZW, and Yao YF collected and analyzed the data; Chen N and Wang L drafted the manuscript.
Supported by National Natural Science Foundation of China , No. 81773214 ; Beijing Municipal Science and Technology Commission (Capital Characteristic Clinical Study) , No. Z15110004015105 ; Beijing Health System High Level Talented Scholar of Medicine Fund (The 215 Project) ; Science Foundation of Peking University Cancer Hospital , No. 2017-13 .
Institutional review board statement: This study was performed under the ethics approval of the Ethic Committee of Beijing Cancer Hospital.
Informed consent statement: All patients were informed and consented.
Conflict-of-interest statement: No competing interest is claimed from all authors.
STROBE statement: The manuscript was revised according to the STROBE.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lin Wang, MD, Assistant Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Center, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China. wanglinmd@foxmail.com
Telephone: +86-10- 88196086 Fax: +86-10-88196086
Received: April 6, 2019
Peer-review started: April 8, 2019
First decision: June 3, 2019
Revised: July 23, 2019
Accepted: August 20, 2019
Article in press: August 21, 2019
Published online: October 15, 2019
Peer-review started: April 8, 2019
First decision: June 3, 2019
Revised: July 23, 2019
Accepted: August 20, 2019
Article in press: August 21, 2019
Published online: October 15, 2019
Core Tip
Core tip: Enhanced lymph node (LN) yield has been noticed to be associated with increasing accuracy in tumor staging and putative prognosis. By the means of fat-clearance technique, the LN retrieval was significantly higher in the fat-clearance group, compared with convention fixation. In terms of survival, however, for patients with negative LN, increased LN harvest was not associated with prolonged survival.