Published online Sep 15, 2018. doi: 10.4251/wjgo.v10.i9.271
Peer-review started: March 30, 2018
First decision: May 9, 2018
Revised: June 8, 2018
Accepted: June 26, 2018
Article in press: June 27, 2018
Published online: September 15, 2018
Core tip: This is a review of recent updates from randomized data and prospective phase I/II trial regarding the role of radiotherapy in the multimodal approach of gastric cancer (GC). The actual state of art is still controversial and in particular adjuvant therapy for locally advanced disease remains undefined in different countries. Recent efforts show that a more intensified local therapy such as radiation therapy cold have a benefit in increasing the disease-free survival, especially in the category of patients with positive pathological lymph nodes. A carefully multidisciplinary evaluation of the patients with GC is then recommended in the clinical practice.