Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2018; 10(10): 317-327
Published online Oct 15, 2018. doi: 10.4251/wjgo.v10.i10.317
Histo-molecular oncogenesis of pancreatic cancer: From precancerous lesions to invasive ductal adenocarcinoma
Giulio Riva, Antonio Pea, Camilla Pilati, Giulia Fiadone, Rita Teresa Lawlor, Aldo Scarpa, Claudio Luchini
Giulio Riva, Giulia Fiadone, Aldo Scarpa, Claudio Luchini, Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona 37134, Italy
Antonio Pea, Department of Surgery, University and Hospital trust of Verona, Verona 37134, Italy
Camilla Pilati, Personalized Medicine, Pharmacogenomics, Therapeutic Optimization, Paris-Descartes University, Paris 75006, France
Rita Teresa Lawlor, ARC-Net Research Center, University and Hospital Trust of Verona, Verona 37134, Italy
Author contributions: Luchini C, Scarpa A and Lawlor RT conceived and designed the study; Riva G, Pea A, Lawlor RT and Luchini C performed the literature review; all authors analyzed and interpreted literature; Riva G, Pea A, Scarpa A and Luchini C wrote the manuscript; all authors edited and approved the manuscript in its present form.
Supported by the Associazione Italiana Ricerca sul Cancro, No. 12182; and Cassini Project.
Conflict-of-interest statement: No potential conflict of interest.
Open-Access: This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Claudio Luchini, MD, PhD, Assistant Professor, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale L.A. Scuro, 10, Verona 37134, Italy.
Telephone: +39-45-8124835 Fax: +39-45-8027136
Received: May 30, 2018
Peer-review started: May 30, 2018
First decision: July 3, 2018
Revised: July 13, 2018
Accepted: August 12, 2018
Article in press: August 13, 2018
Published online: October 15, 2018
Core Tip

Core tip: Pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm are precursor lesions of invasive pancreatic cancer. Each of these precursors displays peculiar histological and molecular features, which have been summarized in this review along with the most important aspects of pancreatic carcinogenesis. The most recent advances and the future perspectives of the research on this topic have also been highlighted.