Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2024; 16(2): 527-542
Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.527
Global research trends and prospects of cellular metabolism in colorectal cancer
Yan-Chen Liu, Zhi-Cheng Gong, Chao-Qun Li, Peng Teng, Yan-Yan Chen, Zhao-Hui Huang
Yan-Chen Liu, Zhi-Cheng Gong, Chao-Qun Li, Peng Teng, Zhao-Hui Huang, Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China
Yan-Chen Liu, Peng Teng, Zhao-Hui Huang, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu Province, China
Yan-Yan Chen, Wuxi Institute of Integrated Chinese and Western Medicine, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu Province, China
Co-corresponding authors: Zhao-Hui Huang and Yan-Yan Chen.
Author contributions: Huang ZH and Chen YY determined the direction of this research; Liu YC analyzed data and wrote the draft; Huang ZH, Chen YY, Gong ZC, Li CQ and Teng P revised and checked the article.
Supported by National Natural Science Foundation of China, No. 82173063 and No. 81972220; Wuxi Taihu Lake Talent Plan Supporting for Leading Talents in Medical and Health Profession; Wuxi Medical Key Discipline, No. ZDXK2021002; China Postdoctoral Science Foundation, No. 2022M711370; Postgraduate Research & Practice Innovation Program of Jiangsu Province, No. KYCX23_2573.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised in accordance with this checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Zhao-Hui Huang, PhD, Professor, Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, No. 200 Huihe Road, Wuxi 214062, Jiangsu Province, China.
Received: November 13, 2023
Peer-review started: November 13, 2023
First decision: December 15, 2023
Revised: December 19, 2023
Accepted: January 5, 2024
Article in press: January 5, 2024
Published online: February 15, 2024
Research background

An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer (CRC).

Research motivation

No work is currently available to synthesize the field through bibliometrics.

Research objectives

To analyze the development in the field of “glucose metabolism” (GM), “amino acid metabolism” (AM), “lipid metabolism” (LM), and “nucleotide metabolism” (NM) in CRC by visualization.

Research methods

Articles within the abovementioned areas of GM, AM, LM and NM in CRC, which were published from January 1, 1991, to December 31, 2022, are retrieved from the Web of Science Core Collection and analyzed by Citespace 6.2.R4 and VOSviewer 1.6.19.

Research results

The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three fields. Meanwhile, cooperation within the countries and authors is also growing. Besides, the research on tumor metabolism in CRC is also gradually deepening the mechanism.

Research conclusions

Research in “cellular metabolism in CRC” is all the rage at the moment, and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in CRC. Targeting metabolic vulnerability appears to be a promising direction in CRC therapy.

Research perspectives

This study tells researchers that metabolic alteration in CRC is one of the most important hallmarks. Future research will not only expand in the four directions listed in the paper, but also produce many other branches and more refined metabolic types. At present, the research on lipid metabolism in CRC is very hot, which provides a future research direction for researchers to study the pathogenesis and development of CRC.