Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1616-1625
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1616
Multidisciplinary discussion and management of synchronous colorectal liver metastases: A single center study in China
Hao Li, Guo-Li Gu, Song-Yan Li, Yang Yan, Shi-Dong Hu, Ze Fu, Xiao-Hui Du
Hao Li, Ze Fu, Graduate School, Medical School of Chinese People’s Liberation Army, Beijing 100039, China
Hao Li, Guo-Li Gu, Department of General Surgery, Air Force Medical Center, Air Force Medical University, Beijing 100142, China
Song-Yan Li, Yang Yan, Shi-Dong Hu, Xiao-Hui Du, Department of General Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100039, China
Author contributions: Li H and Du XH were the guarantor of integrity of entire study, and contributed to the study concepts; Li H, Gu GL, Li SY, and Du XH designed the study; Li H, Gu GL, Li SY, and Hu SD involved in the literature research; Li H and Fu Z contributed to the data acquisition; Li H contributed to the statistical analysis/interpretation and manuscript preparation; Li H, Gu GL, Li SY, Hu SD, and Du XH contributed to the manuscript definition of intellectual content; Li H, Gu GL, and Du XH edited the manuscript.
Supported by National Natural Science Foundation of China, No. 81871317; and Military Medical Innovation Project, No. 18CXZ025.
Institutional review board statement: This study received approval from the ethics commission of the General Hospital of People’s Liberation Army.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: We are committed to promoting open data access. All research data generated as part of this study will be made available to the scientific community and interested parties, subject to legal, ethical, and privacy considerations.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Hui Du, MD, PhD, Chief Doctor, Deputy Director, Professor, Surgeon, Department of General Surgery, Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100039, China. duxiaohui301@sina.com
Received: June 30, 2023
Peer-review started: June 30, 2023
First decision: July 24, 2023
Revised: July 24, 2023
Accepted: August 4, 2023
Article in press: August 4, 2023
Published online: September 15, 2023
ARTICLE HIGHLIGHTS
Research background

Multidisciplinary teams (MDTs) have been implemented in numerous large hospitals; however, critiques persist due to the high costs and limited strong evidence of their effectiveness.

Research motivation

The motivation behind this article is to provide further evidence on the application of MDTs in the field of colorectal liver metastasis. By conducting this research, we aim to contribute to the existing knowledge base and enhance the understanding of how MDTs can effectively improve patient outcomes in this specific context.

Research objectives

The objective of this study is to evaluate the effects of MDTs on patients with synchronous colorectal liver metastases and provide insights and recommendations on the management of synchronous colorectal liver metastases.

Research methods

This retrospective study investigated the influence of MDT involvement on clinical data of patients with synchronous colorectal liver metastases at the Chinese People’s Liberation Army General Hospital.

Research results

The analysis revealed significant statistical increases in the rates of chest computed tomography examination (P = 0.001), abdomen magnetic resonance imaging examination (P = 0.000), and preoperative image staging (P = 0.0000) among patients in the MDT+ group. Furthermore, a higher proportion of patients in the MDT+ group received chemotherapy (P = 0.019) and underwent curative resection (P = 0.042). Multivariable analysis demonstrated that patients assessed through MDT meetings had higher 1-year overall survival [hazard ratio (HR) = 0.608, 95% confidence interval (CI): 0.398-0.931, P = 0.022] and 5-year overall survival (HR = 0.694, 95%CI: 0.515-0.937, P = 0.017).

Research conclusions

The findings of this study provide evidence that MDT management offers patients with synchronous colorectal liver metastases increased access to comprehensive examinations and treatments, ultimately leading to improved outcomes.

Research perspectives

This study conducted from the perspective of surgeons through a retrospective analysis of clinical records, observed that MDT management offers increased opportunities for comprehensive examinations and treatments in patients with synchronous colorectal liver metastases, consequently leading to improved treatment outcomes. This further validates the benefits of MDT management.