Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.970
Peer-review started: June 10, 2021
First decision: June 15, 2021
Revised: June 18, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: August 15, 2021
Exosomes, as tumor molecular markers, have the advantages of protecting the nucleic acids in them and having potential diagnostic value for kinds of diseases. Diagnostic indicator panel may improve the diagnostic value when compared to the single indi
The present study evaluated the diagnostic value of colorectal cancer (CRC) by de
This study aimed to evaluate the potential biomarker-exome miRNA in serum for the diagnosis of CRC.
Relative expression of miR-15b, miR-16, miR-21, and miR-31 in CRC, colorectal ade
A diagnostic model including miR-15b, miR-21, and miR-31 panel for discriminating healthy control group and CRC group was built; the sensitivity and specificity were 95.06% and 94.44%. The sensitivity and specificity of miR-15b, miR-16, and miR-21 panel for discriminating colorectal adenoma group and CRC group were 85.19% and 82.09%, respectively.
The diagnostic value of the exosome four miRNAs (miR-15b, miR-16, miR-21, miR-31) were evaluated and were demonstrated to have potential diagnostic value in serum for CRC.
Although we confirmed the diagnostic value of serum exosome miRNAs for CRC, there remains research to be performed, mostly multi-center studies with a larger sample size.