Case Report
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2017; 9(7): 308-313
Published online Jul 15, 2017. doi: 10.4251/wjgo.v9.i7.308
Goblet cell carcinoid of the appendix and mixed adenoneuroendocrine carcinoma: Report of three cases
Hatice Karaman, Fatma Şenel, Mustafa Güreli, Turan Ekinci, Ömer Topuz
Hatice Karaman, Fatma Şenel, Mustafa Güreli, Turan Ekinci, Department of Pathology, Kayseri Education and Research Hospital, 38030 Kayseri, Turkey
Ömer Topuz, Department of Surgery, Kayseri Education and Research Hospital, 38030 Kayseri, Turkey
Author contributions: All authors contributed to the acquisition of data, writing, and revision of this manuscript.
Institutional review board statement: Kayseri Education and Research Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data.
Conflict-of-interest statement: We have no pertinent financial relationships to disclose
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Hatice Karaman, MD, PROF, Department of Pathology, Kayseri Education and Research Hospital, Alpaslan Mah, Emrah Cad, Beyoğlu Apt, 21/3, 38030 Kayseri, Turkey.
Telephone: +90-352-3368884 Fax: +90-352-3368884
Received: January 19, 2017
Peer-review started: January 23, 2017
First decision: February 17, 2017
Revised: March 15, 2017
Accepted: April 6, 2017
Article in press: April 10, 2017
Published online: July 15, 2017

Neuroendocrine neoplasms are the most common epithelial tumors among appendix tumors. Appendix tumors that are completely or partially composed of neuroendocrine cells are divided into two categories: Classic carcinoid tumors and goblet cell carcinoid tumors (GCCT). They are known to progress more aggressively than classic (neuro) endocrine tumors. In this study, three cases with acute appendicitis symptoms are presented, including their clinical and histopathological findings. Microscopic examination detected GCCT in two cases and mixed adenoneuroendocrine carcinoma in one case, in addition to acute appendicitis.

Keywords: Appendix vermiformis, Mixed adenoneuroendocrine carcinoma, Goblet cell carcinoid tumors

Core tip: Goblet cell carcinoid is a much more aggressive tumor than classic carcinoid, particularly if the tumor shows transmural involvement or if it has extended to the cecum at the time of the operation. This paper presents three cases clinical and histopathological features. Two were diagnosed as goblet cell carcinoid tumor and one was diagnosed as mixed adenoneuroendocrine carcinoma.