Published online Jan 15, 2017. doi: 10.4251/wjgo.v9.i1.30
Peer-review started: August 10, 2016
First decision: September 12, 2016
Revised: September 19, 2016
Accepted: November 16, 2016
Article in press: November 17, 2016
Published online: January 15, 2017
The aging of the population results in a rise of number of elderly patients (aged 80 years and older) with pancreatic or periampullary cancer, and more pancreatectomies could eventually be performed in such complex patients. However, early and long-term results after pancreatic resection in octogenarians are still controversial, and may trouble the surgeon when approaching this type of population. Evaluation of reported experiences shows that for almost all Authors, pancreatectomy can be performed safely in elderly population, although overall morbidity and mortality rates were 34.9% and 13.2% respectively, with a mean length of hospital stay of 18 d. These features appear higher in older patients compared to the younger counterpart. Less than 50% of patients underwent adjuvant therapy after operation. Long-term survival is reported not significantly different in aged 80 years and older patients, with a median overall survival time of 17.6 mo. The quality of life after pancreatic resection is only sporadically evaluated but, when considered, it highlights the need of health facility service after operation for these “frail” patients. Prospective studies on the quality of life of pancreatectomized octogenarians are welcome. Proper selection of patients, geriatric assessment with multidisciplinary approach, centralization of pancreatic surgery in high-volume centres and rehabilitation programs after surgery appear to be crucial points in order to improve surgical treatments of pancreatic tumors in very elderly patients.
Core tip: Although not statistically significant, pancreatic resection in very older patients carried a greater risk of complications, mortality and nursing facility after discharge than in younger patients. Thus, pancreatectomy in 80 years and older patients, should be performed after careful consideration of potential benefit, surgical risk, and patient’s preferences.