Retrospective Study
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World J Gastrointest Oncol. Oct 15, 2014; 6(10): 413-419
Published online Oct 15, 2014. doi: 10.4251/wjgo.v6.i10.413
Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection
HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Martin Luchtefeld, Richard L Whelan
HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States
Martin Luchtefeld, Division of Colon and Rectal Surgery, Ferguson Clinic, Grand Rapids, MI 49546, United States
Richard L Whelan, Icahn School of Medicine at-Mount Sinai, New York, NY 10029, United States
Richard L Whelan, Surgical Oncology, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States
Author contributions: Shantha Kumara HMC contributed to the conception, design, sample processing, analysis and interpretation of data, revision of the articles, final approval of article; Myers EA contributed to the manuscript writing, collection of human material and clinical data, final approval of article; Herath SAC and Yan X contributed to the design, human sample collection, processing, analysis and interpretation of data, final approval of article; Jang JH and Kirchoff D contributed to the collection of human material and clinical data, final approval of article; Njoh L contributed to the statistical analysis, interpretation of data, final approval of article; Cekic V and Luchtefeld M contributed to the collection of human material and clinical data, final approval of article; Whelan RL contributed to the conception, design, interpretation of data, critical revision of the article and final approval of article.
Correspondence to: Richard L Whelan, MD, Professor of Surgery, Chief, Colon and Rectal Surgery, Chief, Surgical Oncology, Department of Surgery, College of Physicians and Surgeons, Columbia University, 116th St and Broadway, New York, NY 10032, United States. rwhelan@chpnet.org
Telephone: +1-212-5238172 Fax: +1-212-5238857
Received: April 30, 2014
Revised: August 20, 2014
Accepted: September 16, 2014
Published online: October 15, 2014
Abstract

AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer (CRC) and benign patients and postoperatively after CRC resection.

METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection (MICR) for CRC and benign disease (BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples (postoperative day 7-27) were available. Monocyte chemotactic protein-1 (MCP-1) levels (pg/mL) were determined via enzyme linked immuno-absorbent assay.

RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient’s median preoperative MCP-1 level (283.1, CI: 256.0, 294.3) was higher than the BEN group level (227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1 (446.3, CI: 418.0, 520.1), postoperative day 3 (342.7, CI: 320.4, 377.4), postoperative day 7-13 (326.5, CI: 299.4, 354.1), postoperative day 14-20 (361.6, CI: 287.8, 407.9), and postoperative day 21-27 (318.1, CI: 287.2, 371.6; P < 0.001 for all).

CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients (vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.

Keywords: Colorectal cancer, Monocyte chemotactic protein-1, Minimally invasive colorectal resection angiogenesis

Core tip: In our past published studied we have shown that plasma levels of the pro-angiogenic proteins, vascular endothelial growth factor, angiopoietin-2, placental growth factor, and soluble vascular adhesion molecule-1, are significantly elevated for 2-4 wk following minimally invasive colorectal resection for colorectal cancer (CRC). Additionally, we also showed that postoperative plasma from cancer patients stimulates in vitro endothelial cell proliferation, migration, and invasion, all of which are critical steps in angiogenesis. In this manuscript we are presenting data to show that plasma Monocyte chemotactic protein-1 (MCP-1), a pro-angiogenic protein, in CRC patients remain elevated for month after MICR. Furthermore, we are also showing that the median preoperative plasma level of MCP-1 is significantly higher in the CRC patients than in the BEN group.