Case Report
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World J Gastrointest Oncol. Mar 15, 2013; 5(3): 68-70
Published online Mar 15, 2013. doi: 10.4251/wjgo.v5.i3.68
Gastroesophageal cancer and retroperitoneal fibrosis: Two case reports and review of the literature
Renata D’Alpino Peixoto, Jasem Al-Barrak, Howard Lim, Daniel Renouf
Renata D’Alpino Peixoto, Jasem Al-Barrak, Howard Lim, Daniel Renouf, Department of Medical Oncology, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada
Author contributions: Peixoto RD, Lim H and Renouf D designed the report; Lim H and Renouf D were attending doctors for the patients; Peixoto RD, Al-Barrak J, Lim H and Renouf D organized the report; Peixoto RD, Al-Barrak J, Lim H and Renouf D wrote paper.
Correspondence to: Renata D’Alpino Peixoto, MD, Department of Medical Oncology, BC Cancer Agency, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Canada. renatadalpino@gmail.com
Telephone: +1-604-8776000 Fax: +1-604-8770585
Received: December 4, 2012
Revised: January 17, 2013
Accepted: January 23, 2013
Published online: March 15, 2013
Processing time: 127 Days and 8.8 Hours
Abstract

Retroperitoneal fibrosis secondary to malignant disease is a rare condition associated with a dismal prognosis. We herein present the first ever reported case of retroperitoneal fibrosis related to esophageal adenocarcinoma in a 63-year-old patient who developed bilateral ureteral obstruction due to extensive retroperitoneal fibrosis 18 mo after having completed neoadjuvant chemoradation followed by surgery for a pT3N0 adenocarcinoma of the distal esophagus. We also report the case of a previously healthy woman who presented with bilateral ureteral obstruction and diffuse narrowing of the common biliary duct and was found to have extensive retroperitoneal fibrosis as a consequence of metastatic gastric adenocarcinoma. Both patients had poor performance status and were unsuitable for palliative chemotherapy. This paper shows that urinary and biliary obstructive symptoms might represent retroperitoneal fibrosis as a consequence of gastroesophageal malignancy.

Keywords: Gastric cancer; Esophageal cancer; Retroperitoneal fibrosis