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©2012 Baishideng. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2012; 4(6): 152-155
Published online Jun 15, 2012. doi: 10.4251/wjgo.v4.i6.152
Published online Jun 15, 2012. doi: 10.4251/wjgo.v4.i6.152
Bone lesions in recurrent glucagonoma: A case report and review of literature
Cristian Ghetie, Danbury Hospital, Danbury, CT 06810, United States
Daniel Cornfeld, Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT 06510, United States
Vassilios S Ramfidis, Kostas N Syrigos, Oncology Unit, Third Department of Medicine, Sotiria General Hospital, Athens Medical School, Athens 11527, Greece
Kostas N Syrigos, Section of Medical Oncology, Yale School of Medicine, New Haven, CT 06510, United States
Muhammad W Saif, Division of Hematology and Oncology, Department of Medicine, Columbia University, NY 10032, United States
Author contributions: All authors contributed to this manuscript.
Correspondence to: Konstantinos N Syrigos, MD, PhD, Professor, Head, Oncology Unit, Third Department of Medicine, Sotiria General Hospital, Athens University School of Medicine, Building Z, Mesogion 152, Athens 11527, Greece. ksyrigos@med.uoa.gr
Telephone: +30-210-7475034 Fax: +30-210-7781035
Received: January 25, 2012
Revised: February 22, 2012
Accepted: March 2, 2012
Published online: June 15, 2012
Revised: February 22, 2012
Accepted: March 2, 2012
Published online: June 15, 2012
Abstract
Glucagonomas are rare neuroendocrine tumors that arise from α cells of the pancreatic islets. Most of them are malignant and usually present as metastatic disease. Sites most commonly involved in metastases are the liver and regional lymph nodes. Bone metastases are rare events and only a few cases have been reported in the literature. We present the case of a 53-year-old male with a medical history of recurrent non-functioning glucagonoma. He presented 17 years after the initial diagnosis with new blastic bone lesions involving the T1 vertebra and the sacrum. Diagnostic steps and medical management in metastatic glucagonoma are also reviewed.
Keywords: Glucagonoma, Bone metastases, Blastic lesion, Octreoscan