Argyropoulos T, Foukas P, Kefala M, Xylardistos P, Papageorgiou S, Machairas N, Boltetsou E, Machairas A, Panayiotides IG. Simultaneous occurrence of colonic adenocarcinoma and MALT lymphoma: A series of three cases. World J Gastrointest Oncol 2012; 4(4): 89-93 [PMID: 22532883 DOI: 10.4251/wjgo.v4.i4.89]
Corresponding Author of This Article
Theodoros Argyropoulos, MD, 2nd Department of Pathology, University of Athens Medical School, “Attikon” University Hospital, Rimini1, GR-12464, Chaidari, Greece. argyropoulostheodoros@gmail.com
Article-Type of This Article
Case Report
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World J Gastrointest Oncol. Apr 15, 2012; 4(4): 89-93 Published online Apr 15, 2012. doi: 10.4251/wjgo.v4.i4.89
Simultaneous occurrence of colonic adenocarcinoma and MALT lymphoma: A series of three cases
Theodoros Argyropoulos, Periklis Foukas, Maria Kefala, Panagiotis Xylardistos, Sotirios Papageorgiou, Nikolaos Machairas, Evmorfia Boltetsou, Anastasios Machairas, Ioannis G Panayiotides
Theodoros Argyropoulos, Periklis Foukas, Maria Kefala, Evmorfia Boltetsou, Ioannis G Panayiotides, 2nd Department of Pathology, University of Athens Medical School, “Attikon” University Hospital, Rimini1, GR-12464, Chaidari, Greece
Panagiotis Xylardistos, Nikolaos Machairas, Anastasios Machairas, 3rd Department of Surgery, University of Athens Medical School, “Attikon” University Hospital, Rimini1, GR-12464, Chaidari, Greece
Sotirios Papageorgiou, Haematology Unit, 2nd Department of Internal Medicine - Propaedeutic, University of Athens Medical School, “Attikon” University Hospital, Rimini1, GR-12464, Chaidari, Greece
Author contributions: Machairas N, Machairas A and Xylardistos P performed surgical excisions and provided clinical data; Argyropoulos T, Foukas P and Panayiotides IG analyzed the data; Foukas P and Boltetsou E reviewed slides and contributed to the histological diagnosis; Papageorgiou S provided oncological data; Argyropoulos T, Foukas P and Kefala M wrote the paper.
Correspondence to: Theodoros Argyropoulos, MD, 2nd Department of Pathology, University of Athens Medical School, “Attikon” University Hospital, Rimini1, GR-12464, Chaidari, Greece. argyropoulostheodoros@gmail.com
Telephone: +30-697-3883043 Fax: +30-210-5831949
Received: November 16, 2011 Revised: January 14, 2012 Accepted: January 25, 2012 Published online: April 15, 2012
Abstract
Simultaneous development of adenocarcinoma and primary B cell lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma of the colon is rare; only one case has so far been reported out of 13 cases with the coexistence of colonic adenocarcinoma with involvement of the colon by lymphoma. We hereby present three more cases, two females (aged 75 and 71 years) and a male (aged 72 years). All three underwent colectomy based on a preoperative biopsy revealing colonic carcinoma. Histological examination of the resection specimens disclosed a colonic adenocarcinoma in two cases, whereas a tubulovillous adenoma with superficial foci of intraepithelial adenocarcinoma was seen in the third case. Moreover, in all three cases, a coexisting MALT lymphoma was diagnosed in the colon (1 case), in both colon and adjacent lymph nodes (1 case) or in colonic lymph nodes and omentum (1 case). In the last case, a post-operative bone marrow biopsy revealed extensive infiltration of the bone marrow, due to which the patient received postoperative chemotherapy. Diagnostic and treatment issues are briefly discussed.
