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World J Gastrointest Oncol. Jan 15, 2011; 3(1): 14-18
Published online Jan 15, 2011. doi: 10.4251/wjgo.v3.i1.14
Primary colorectal lymphoma: An overview
Goran Z Stanojevic, Milica D Nestorovic, Branko R Brankovic, Miroslav P Stojanovic, Milan M Jovanovic, Milan D Radojkovic
Goran Z Stanojevic, Milica D Nestorovic, Branko R Brankovic, Miroslav P Stojanovic, Milan M Jovanovic, Milan D Radojkovic, Clinic for General Surgery, Clinical Center Nis, Bul Zorana Djindjica 48, 18000 Nis, Serbia
Author contributions: Stanojevic GZ contributed substantially to conception and design; Nestorovic MD and Brankovic BR contributed to data acquisition; Nestorovic MD and Radojkovic MD contributed to analysis and interpretation of data; Stojanovic MP and Jovanovic MM drafted the article and revised it critically for important intellectual content; Stanojevic GP gave final approval of the version to be published.
Correspondence to: Goran Z Stanojevic, MD, PhD, Professor, Clinic for General Surgery, Medical Faculty, University of Nis, Bul Zorana Djindjica 48, 18000 Nis, Serbia.
Telephone: +381-18-506946 Fax: +381-18-596006
Received: September 15, 2010
Revised: December 20, 2010
Accepted: December 27, 2010
Published online: January 15, 2011

Lymphomas represent common hematological malignancies with increasing incidence in recent years. The major site of extranodal non-Hodgkin lymphoma is the gastrointestinal tract. Involvement of the large intestine is rare in comparison to the stomach or small bowel. The disease appears later in life, predominantly in the male population. Complaints are nonspecific, requiring a high index of suspicion in order to establish the diagnosis. The treatment varies from chemotherapy alone to multimodal therapies combining surgery, chemotherapy and radiotherapy. The small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal lymphoma. The purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject.

Keywords: Lymphoma non-Hodgkin, Extranodal lymphoma, Large intestine, Colorectal surgery, Chemotherapy