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World J Gastrointest Oncol. Sep 15, 2010; 2(9): 342-347
Published online Sep 15, 2010. doi: 10.4251/wjgo.v2.i9.342
Published online Sep 15, 2010. doi: 10.4251/wjgo.v2.i9.342
Gastric cancer, Helicobacter pylori infection and other risk factors
Lorenzo Fuccio, Leonardo Henry Eusebi, Franco Bazzoli, Department of Internal Medicine and Gastroenterology, University of Bologna, 40138 Bologna, Italy
Author contributions: Each author was involved with all stages of manuscript development
Correspondence to: Franco Bazzoli, Professor, Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy. franco.bazzoli@unibo.it
Telephone: +39-51-6364106 Fax: +39-51-343926
Received: January 16, 2010
Revised: August 17, 2010
Accepted: August 24, 2010
Published online: September 15, 2010
Revised: August 17, 2010
Accepted: August 24, 2010
Published online: September 15, 2010
Abstract
Gastric cancer incidence is declining. However, it is too early to consider this neoplastic disease as rare and the worldwide mortality rate still remains high. Several risk factors have been identified for non-cardia gastric cancer and primary prevention is feasible since most of the risk factors can be removed. Helicobacter pylori eradication treatment reduces but does not abolish gastric cancer risk. Indeed, gastric cancer is a multifactorial disease and removing one factor does not therefore prevent all cases. Endoscopic surveillance is still needed, especially in subjects at higher risk. The definition of high-risk patients will be the future challenge as well as identifying the best surveillance strategy for such patients.
Keywords: Helicobacter pylori, Eradication treatment, Diet, Gastric cancer