Fan X, Fan YT, Zeng H, Dong XQ, Lu M, Zhang ZY. Role of ferroptosis in esophageal cancer and corresponding immunotherapy. World J Gastrointest Oncol 2023; 15(7): 1105-1118 [PMID: 37546564 DOI: 10.4251/wjgo.v15.i7.1105]
Corresponding Author of This Article
Zhi-Yuan Zhang, PhD, Doctor, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330000, Jiangxi Province, China. zzyent@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xin Fan, Zhi-Yuan Zhang, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
Yan-Ting Fan, Xi-Qi Dong, The First Clinical Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China
Hui Zeng, Department of Stomatology, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
Min Lu, Department of Emergency Medicine, Shangrao Hospital Affiliated to Nanchang University, Shangrao 334000, Jiangxi Province, China
Author contributions: Fan X and Fan YT drafted the manuscript; Zeng H, Dong XQ, Lu M and Zhang ZY contributed to the editing of the manuscript; all authors contributed to the article and approved the submitted version.
Supported bythe Central Funds Guiding the Local Science and Technology Development of China, No. 20221ZDG020066.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Yuan Zhang, PhD, Doctor, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330000, Jiangxi Province, China. zzyent@126.com
Received: December 28, 2022 Peer-review started: December 28, 2022 First decision: January 12, 2023 Revised: February 28, 2023 Accepted: April 24, 2023 Article in press: April 24, 2023 Published online: July 15, 2023
Abstract
Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis and autophagy. In recent years, many studies have further enlightened that ferroptosis plays an essential role in the occurrence, development and metastasis of tumors. Targeting ferroptosis stimulates a new direction for further exploration of oncologic treatment regimens. Furthermore, ferroptosis has a critical role in the immune microenvironment of tumors. This paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.
Core Tip: Recent studies suggested that ferroptosis plays an important role in the development, progression and metastasis of esophageal cancer (EC). Meanwhile, ferroptosis influences the outcome of immunotherapy to some extent. This review aims to elucidate the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.
