Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Hoelzinger DB, Mariani L, Weis J, Woyke T, Berens TJ, McDonough WS, Sloan A, Coons SW, Berens ME. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia 2005;7:7-16. [PMID: 15720813 PMCID: PMC1490313 DOI: 10.1593/neo.04535] [Citation(s) in RCA: 252] [Impact Index Per Article: 12.6] [Reference Citation Analysis] [What about the content of this article? (0)] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/21/2022] Open

For:	Hoelzinger DB, Mariani L, Weis J, Woyke T, Berens TJ, McDonough WS, Sloan A, Coons SW, Berens ME. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia 2005;7:7-16. [PMID: 15720813 PMCID: PMC1490313 DOI: 10.1593/neo.04535] [Citation(s) in RCA: 252] [Impact Index Per Article: 12.6] [Reference Citation Analysis] [What about the content of this article? (0)] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/21/2022] Open

Number

Cited by Other Article(s)

Togni A, Piermartiri T, Tasca CI, Nedel CB. The intricate relationship between SUMOylation and gliomas: a review with a perspective on natural compounds. Nat Prod Res 2025:1-12. [PMID: 39849680 DOI: 10.1080/14786419.2025.2456093] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/20/2023] [Revised: 12/31/2024] [Accepted: 01/16/2025] [Indexed: 01/25/2025]

Villegas-Vazquez EY, Marín-Carrasco FP, Reyes-Hernández OD, Báez-González AS, Bustamante-Montes LP, Padilla-Benavides T, Quintas-Granados LI, Figueroa-González G. Revolutionizing ovarian cancer therapy by drug repositioning for accelerated and cost-effective treatments. Front Oncol 2025;14:1514120. [PMID: 39876896 PMCID: PMC11772297 DOI: 10.3389/fonc.2024.1514120] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/20/2024] [Accepted: 12/23/2024] [Indexed: 01/31/2025] Open

Crestani M, Kakogiannos N, Iori S, Iannelli F, Dini T, Maderna C, Giannotta M, Pelicci G, Maiuri P, Monzo P, Gauthier NC. Biomimetic Approach of Brain Vasculature Rapidly Characterizes Inter- and Intra-Patient Migratory Diversity of Glioblastoma. SMALL METHODS 2024;8:e2400210. [PMID: 38747088 PMCID: PMC11671864 DOI: 10.1002/smtd.202400210] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/08/2024] [Revised: 05/04/2024] [Indexed: 12/28/2024]

Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Grimaldo-Garcia S, Metzger B, Bolus V, Kopper TJ, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW. Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells. Neurol Int 2024;16:1355-1384. [PMID: 39585062 PMCID: PMC11587087 DOI: 10.3390/neurolint16060103] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2024] [Revised: 10/23/2024] [Accepted: 11/01/2024] [Indexed: 11/26/2024] Open

Affiliation(s)

Mary Wang Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Arin N. Graner Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Bryne Knowles Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
Charlotte McRae Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Anthony Fringuello Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Department of Cell Biology, State University of New York Downstate Health Sciences University, New York, NY 11203, USA
Petr Paucek Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Michael Gavrilovic Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Department of Biomedical Sciences, Regis University, Denver, CO 80221, USA St Louis University School of Medicine, St. Louis, MO 63104, USA
McKenna Redwine Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Department of Biomedical Sciences, Regis University, Denver, CO 80221, USA
Caleb Hanson Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Department of Biomedical Sciences, Regis University, Denver, CO 80221, USA
Christina Coughlan Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA;
Stacey Grimaldo-Garcia Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Department of Neuroscience, Middlebury College, Middlebury, VT 05753, USA
Brooke Metzger Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Occupational Therapy, Illinois College, Jacksonville, IL 62650, USA Neuroscience, Midwestern University, Glendale, AZ 85308, USA
Vince Bolus Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Timothy J. Kopper Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Marie Smith Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Wenbo Zhou Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Morgan Lenz Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.) Occupational Therapy, Illinois College, Jacksonville, IL 62650, USA
Aviva Abosch Department of Neurosurgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA;
Steven Ojemann Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Kevin O. Lillehei Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Xiaoli Yu Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)
Michael W. Graner Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; (M.W.); (A.N.G.); (B.K.); (C.M.); (A.F.); (P.P.); (M.G.); (M.R.); (C.H.); (S.G.-G.); (B.M.); (V.B.); (T.J.K.); (M.S.); (W.Z.); (M.L.); (S.O.); (K.O.L.); (X.Y.)

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Sharma A, Raut SS, Shukla A, Gupta S, Singh A, Mishra A. DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay. Med Oncol 2024;41:258. [PMID: 39368002 DOI: 10.1007/s12032-024-02525-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/18/2024] [Accepted: 09/23/2024] [Indexed: 10/07/2024]

Jha RM, Rajasundaram D, Sneiderman C, Schlegel BT, O'Brien C, Xiong Z, Janesko-Feldman K, Trivedi R, Vagni V, Zusman BE, Catapano JS, Eberle A, Desai SM, Jadhav AP, Mihaljevic S, Miller M, Raikwar S, Rani A, Rulney J, Shahjouie S, Raphael I, Kumar A, Phuah CL, Winkler EA, Simon DW, Kochanek PM, Kohanbash G. A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets. Neuron 2024;112:3069-3088.e4. [PMID: 39019041 DOI: 10.1016/j.neuron.2024.06.021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/28/2023] [Revised: 05/07/2024] [Accepted: 06/20/2024] [Indexed: 07/19/2024]

Affiliation(s)

Ruchira M Jha Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Safar Center for Resuscitation-Research, University of Pittsburgh, Pittsburgh, PA 15224, USA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Dhivyaa Rajasundaram Department of Pediatrics, Division of Health Informatics, University of Pittsburgh, Pittsburgh, PA 15224, USA
Chaim Sneiderman Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brent T Schlegel Department of Pediatrics, Division of Health Informatics, University of Pittsburgh, Pittsburgh, PA 15224, USA
Casey O'Brien Department of Pediatrics, Division of Health Informatics, University of Pittsburgh, Pittsburgh, PA 15224, USA
Zujian Xiong Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Keri Janesko-Feldman Safar Center for Resuscitation-Research, University of Pittsburgh, Pittsburgh, PA 15224, USA
Ria Trivedi Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Vincent Vagni Safar Center for Resuscitation-Research, University of Pittsburgh, Pittsburgh, PA 15224, USA
Benjamin E Zusman Department of Neurology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA
Joshua S Catapano Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Adam Eberle Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Shashvat M Desai Honorhealth Research Institute, Scottsdale, AZ 85258, USA
Ashutosh P Jadhav Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Sandra Mihaljevic Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Margaux Miller Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Sudhanshu Raikwar Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Anupama Rani Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Jarrod Rulney University of Arizona School of Medicine, Tucson, AZ 85724, USA
Shima Shahjouie Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Neurology, Pennsylvania State University, Hershey, PA 17033, USA
Itay Raphael Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Aditya Kumar Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Chia-Ling Phuah Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA; Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Ethan A Winkler Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA
Dennis W Simon Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
Patrick M Kochanek Safar Center for Resuscitation-Research, University of Pittsburgh, Pittsburgh, PA 15224, USA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Gary Kohanbash Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA

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Laface C, Ricci AD, Vallarelli S, Ostuni C, Rizzo A, Ambrogio F, Centonze M, Schirizzi A, De Leonardis G, D’Alessandro R, Lotesoriere C, Giannelli G. Autotaxin-Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic Implications. Int J Mol Sci 2024;25:7737. [PMID: 39062979 PMCID: PMC11277072 DOI: 10.3390/ijms25147737] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Revised: 07/03/2024] [Accepted: 07/11/2024] [Indexed: 07/28/2024] Open

Affiliation(s)

Carmelo Laface Medical Oncology Unit, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy
Angela Dalia Ricci Medical Oncology Unit, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy
Simona Vallarelli Medical Oncology Unit, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy
Carmela Ostuni Medical Oncology Unit, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy
Alessandro Rizzo Medical Oncology, IRCCS Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, Italy
Francesca Ambrogio Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, Italy
Matteo Centonze Personalized Medicine Laboratory, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy;
Annalisa Schirizzi Laboratory of Experimental Oncology, National Institute of Gastroenterology, “IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy; (A.S.); (G.D.L.)
Giampiero De Leonardis Laboratory of Experimental Oncology, National Institute of Gastroenterology, “IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy; (A.S.); (G.D.L.)
Rosalba D’Alessandro Laboratory of Experimental Oncology, National Institute of Gastroenterology, “IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy; (A.S.); (G.D.L.)
Claudio Lotesoriere Medical Oncology Unit, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy
Gianluigi Giannelli Scientific Direction, National Institute of Gastroenterology, IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy

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Alorfi NM, Ashour AM, Alharbi AS, Alshehri FS. Targeting inflammation in glioblastoma: An updated review from pathophysiology to novel therapeutic approaches. Medicine (Baltimore) 2024;103:e38245. [PMID: 38788009 PMCID: PMC11124608 DOI: 10.1097/md.0000000000038245] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/09/2024] [Accepted: 04/25/2024] [Indexed: 05/26/2024] Open

Chatzikalil E, Stergiou IE, Papadakos SP, Konstantinidis I, Theocharis S. The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies. Int J Mol Sci 2024;25:3834. [PMID: 38612645 PMCID: PMC11011407 DOI: 10.3390/ijms25073834] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/27/2024] [Revised: 03/26/2024] [Accepted: 03/26/2024] [Indexed: 04/14/2024] Open

Simonetti J, Ficili M, Sgalla G, Richeldi L. Experimental autotaxin inhibitors for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs 2024;33:133-143. [PMID: 38299617 DOI: 10.1080/13543784.2024.2305126] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/23/2023] [Accepted: 01/10/2024] [Indexed: 02/02/2024]

Dong F, Liu Y, Yan W, Meng Q, Song X, Cheng B, Yao R. Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors. Cell Mol Neurobiol 2023;43:1663-1683. [PMID: 36350538 PMCID: PMC11412186 DOI: 10.1007/s10571-022-01279-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2022] [Accepted: 08/26/2022] [Indexed: 11/11/2022]

Miyai M, Iwama T, Hara A, Tomita H. Exploring the Vital Link Between Glioma, Neuron, and Neural Activity in the Context of Invasion. THE AMERICAN JOURNAL OF PATHOLOGY 2023;193:669-679. [PMID: 37286277 DOI: 10.1016/j.ajpath.2023.02.018] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/03/2022] [Revised: 02/15/2023] [Accepted: 02/23/2023] [Indexed: 06/09/2023]

Garcia-Diaz C, Pöysti A, Mereu E, Clements MP, Brooks LJ, Galvez-Cancino F, Castillo SP, Tang W, Beattie G, Courtot L, Ruiz S, Roncaroli F, Yuan Y, Marguerat S, Quezada SA, Heyn H, Parrinello S. Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin. Cell Rep 2023;42:112472. [PMID: 37149862 DOI: 10.1016/j.celrep.2023.112472] [Citation(s) in RCA: 15] [Impact Index Per Article: 7.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/25/2022] [Revised: 03/14/2023] [Accepted: 04/19/2023] [Indexed: 05/09/2023] Open

Affiliation(s)

Claudia Garcia-Diaz Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK
Anni Pöysti Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK
Elisabetta Mereu CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain
Melanie P Clements Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK
Lucy J Brooks Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK
Felipe Galvez-Cancino Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK
Simon P Castillo Division of Molecular Pathology & Centre for Evolution and Cancer, The Institute of Cancer Research, London SM2 5NG, UK
Wenhao Tang Department of Mathematics, Imperial College London, London, UK
Gordon Beattie CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK
Lilas Courtot Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK
Sara Ruiz CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain
Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, School of Biological Sciences, Faculty of Brain and Mental Health, University of Manchester, Manchester, UK
Yinyin Yuan Division of Molecular Pathology & Centre for Evolution and Cancer, The Institute of Cancer Research, London SM2 5NG, UK
Samuel Marguerat Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK
Sergio A Quezada Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK
Holger Heyn CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain
Simona Parrinello Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK.

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Giambra M, Di Cristofori A, Valtorta S, Manfrellotti R, Bigiogera V, Basso G, Moresco RM, Giussani C, Bentivegna A. The peritumoral brain zone in glioblastoma: where we are and where we are going. J Neurosci Res 2023;101:199-216. [PMID: 36300592 PMCID: PMC10091804 DOI: 10.1002/jnr.25134] [Citation(s) in RCA: 17] [Impact Index Per Article: 8.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/23/2022] [Revised: 09/01/2022] [Accepted: 10/01/2022] [Indexed: 12/13/2022]

Méaux MN, Regnier M, Portefaix A, Borel O, Alioli C, Peyruchaud O, Legrand M, Bacchetta J. Circulating autotaxin levels in healthy teenagers: Data from the Vitados cohort. Front Pediatr 2023;11:1094705. [PMID: 36861069 PMCID: PMC9969100 DOI: 10.3389/fped.2023.1094705] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/10/2022] [Accepted: 01/16/2023] [Indexed: 02/17/2023] Open

Abstract

Autotaxin (ATX) is a secreted enzyme with a lysophospholipase D activity, mainly secreted by adipocytes and widely expressed. Its major function is to convert lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), an essential bioactive lipid involved in multiple cell processes. The ATX-LPA axis is increasingly studied because of its involvement in numerous pathological conditions, more specifically in inflammatory or neoplastic diseases, and in obesity. Circulating ATX levels gradually increase with the stage of some pathologies, such as liver fibrosis, thus making them a potentially interesting non-invasive marker for fibrosis estimation. Normal circulating levels of ATX have been established in healthy adults, but no data exist at the pediatric age. The aim of our study is to describe the physiological concentrations of circulating ATX levels in healthy teenagers through a secondary analysis of the VITADOS cohort. Our study included 38 teenagers of Caucasian origin (12 males, 26 females). Their median age was 13 years for males and 14 years for females, ranging from Tanner 1 to 5. BMI was at the 25th percentile for males and 54th percentile for females, and median blood pressure was normal. ATX median levels were 1,049 (450-2201) ng/ml. There was no difference in ATX levels between sexes in teenagers, which was in contrast to the male and female differences described in the adult population. ATX levels significantly decreased with age and pubertal status, reaching adult levels at the end of puberty. Our study also suggested positive correlations between ATX levels and blood pressure (BP), lipid metabolism, and bone biomarkers. However, except for LDL cholesterol, these factors were also significantly correlated with age, which might be a confounding factor. Still, a correlation between ATX and diastolic BP was described in obese adult patients. No correlation was found between ATX levels and inflammatory marker C-reactive protein (CRP), Body Mass Index (BMI), and biomarkers of phosphate/calcium metabolism. In conclusion, our study is the first to describe the decline in ATX levels with puberty and the physiological concentrations of ATX levels in healthy teenagers. It will be of utmost importance when performing clinical studies in children with chronic diseases to keep these kinetics in mind, as circulating ATX might become a non-invasive prognostic biomarker in pediatric chronic diseases.

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Vít O, Petrák J. Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer. Folia Biol (Praha) 2023;69:149-162. [PMID: 38583176 DOI: 10.14712/fb2023069050149] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/09/2024]

Lee D, Hong JH. Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis. Int J Mol Sci 2022;23:ijms232415475. [PMID: 36555115 PMCID: PMC9779422 DOI: 10.3390/ijms232415475] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2022] [Revised: 11/28/2022] [Accepted: 12/05/2022] [Indexed: 12/12/2022] Open

Drosouni A, Panagopoulou M, Aidinis V, Chatzaki E. Autotaxin in Breast Cancer: Role, Epigenetic Regulation and Clinical Implications. Cancers (Basel) 2022;14:5437. [PMID: 36358855 PMCID: PMC9658281 DOI: 10.3390/cancers14215437] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/15/2022] [Revised: 10/31/2022] [Accepted: 10/31/2022] [Indexed: 08/02/2023] Open

Wang S, Chen J, Guo XZ. KAI1/CD82 gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers. World J Gastrointest Oncol 2022;14:1388-1405. [PMID: 36160748 PMCID: PMC9412925 DOI: 10.4251/wjgo.v14.i8.1388] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/11/2021] [Revised: 01/06/2022] [Accepted: 07/22/2022] [Indexed: 02/05/2023] Open

Islam MK, Islam MR, Rahman MH, Islam MZ, Amin MA, Ahmed KR, Rahman MA, Moni MA, Kim B. Bioinformatics Strategies to Identify Shared Molecular Biomarkers That Link Ischemic Stroke and Moyamoya Disease with Glioblastoma. Pharmaceutics 2022;14:1573. [PMID: 36015199 PMCID: PMC9413912 DOI: 10.3390/pharmaceutics14081573] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/12/2022] [Revised: 07/17/2022] [Accepted: 07/19/2022] [Indexed: 12/01/2022] Open

Ahmed MB, Alghamdi AAA, Islam SU, Lee JS, Lee YS. cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach. Cells 2022;11:cells11132020. [PMID: 35805104 PMCID: PMC9266045 DOI: 10.3390/cells11132020] [Citation(s) in RCA: 63] [Impact Index Per Article: 21.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2022] [Revised: 06/17/2022] [Accepted: 06/23/2022] [Indexed: 02/01/2023] Open

Li Q, Aishwarya S, Li JP, Pan DX, Shi JP. Gene Expression Profiling of Glioblastoma to Recognize Potential Biomarker Candidates. Front Genet 2022;13:832742. [PMID: 35571016 PMCID: PMC9091202 DOI: 10.3389/fgene.2022.832742] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2021] [Accepted: 03/23/2022] [Indexed: 01/09/2023] Open

Abstract

Glioblastoma is an aggressive malignant tumor of the brain and spinal cord. Due to the blood-brain barrier, the accessibility of its treatments still remains significantly challenging. Unfortunately, the recurrence rates of glioblastoma upon surgery are very high too. Hence, understanding the molecular drivers of disease progression is valuable. In this study, we aimed to investigate the molecular drivers responsible for glioblastoma progression and identify valid biomarkers. Three microarray expression profiles GSE90604, GSE50601, and GSE134470 containing healthy and glioblastoma-affected samples revealed overlapping differentially expressed genes (DEGs). The interrelational pathway enrichment analysis elucidated the halt of cell cycle checkpoints and activation of signaling pathways and led to the identification of 6 predominant hub genes. Validation of hub genes in comparison with The Cancer Genome Atlas datasets identified the potential biomarkers of glioblastoma. The study evaluated two significantly upregulated genes, SPARC (secreted protein acidic and rich in cysteine) and VIM (vimentin) for glioblastoma. The genes CACNA1E (calcium voltage-gated channel subunit alpha1 e), SH3GL2 (SH3 domain-containing GRB2-like 2, endophilin A1), and DDN (dendrin) were identified as under-expressed genes as compared to the normal and pan-cancer tissues along with prominent putative prognostic biomarker potentials. The genes DDN and SH3GL2 were found to be upregulated in the proneural subtype, while CACNA1E in the mesenchymal subtype of glioblastoma exhibits good prognostic potential. The mutational analysis also revealed the benign, possibly, and probably damaging substitution mutations. The correlation between the DEG and survival in glioblastoma was evaluated using the Kaplan-Meier plots, and VIM had a greater life expectancy of 60.25 months. Overall, this study identified key candidate genes that might serve as predictive biomarkers for glioblastoma.

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Zhu B, Li Y, Mao X. A review on the role of different ephrins in glioma. Eur J Pharmacol 2022;917:174588. [PMID: 34688637 DOI: 10.1016/j.ejphar.2021.174588] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/08/2021] [Revised: 10/18/2021] [Accepted: 10/19/2021] [Indexed: 01/16/2023]

Huang Q, Wang K, Wanggou S, Tian J, Li X. A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma. NANOMEDICINE : NANOTECHNOLOGY, BIOLOGY, AND MEDICINE 2022;40:102509. [PMID: 34915180 DOI: 10.1016/j.nano.2021.102509] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/27/2021] [Revised: 10/25/2021] [Accepted: 11/22/2021] [Indexed: 05/16/2023]

Safaee MM, Wang EJ, Jain S, Chen JS, Gill S, Zheng AC, Garcia JH, Beniwal AS, Tran Y, Nguyen AT, Trieu M, Leung K, Wells J, Maclean JM, Wycoff K, Aghi MK. CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma. Sci Rep 2022;12:1464. [PMID: 35087132 PMCID: PMC8795421 DOI: 10.1038/s41598-022-05259-y] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/30/2021] [Accepted: 01/03/2022] [Indexed: 12/12/2022] Open

Affiliation(s)

Michael M Safaee Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Elaina J Wang Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Saket Jain Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Jia-Shu Chen Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Sabraj Gill Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Allison C Zheng Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Joseph H Garcia Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Angad S Beniwal Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Y Tran Planet Biotechnology, Inc., Hayward, CA, USA
Alan T Nguyen Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA
Melissa Trieu School of Pharmacy, University of California, San Francisco (UCSF), San Francisco, USA
Kevin Leung School of Pharmacy, University of California, San Francisco (UCSF), San Francisco, USA
Jim Wells School of Pharmacy, University of California, San Francisco (UCSF), San Francisco, USA
James M Maclean Planet Biotechnology, Inc., Hayward, CA, USA
Keith Wycoff Planet Biotechnology, Inc., Hayward, CA, USA
Manish K Aghi Department of Neurological Surgery, Brain Tumor Center, Helen Diller Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, USA.

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Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives. Cancers (Basel) 2022;14:cancers14020443. [PMID: 35053605 PMCID: PMC8773542 DOI: 10.3390/cancers14020443] [Citation(s) in RCA: 101] [Impact Index Per Article: 33.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/24/2021] [Accepted: 01/04/2022] [Indexed: 12/12/2022] Open

Wesley UV, Sutton I, Clark PA, Cunningham K, Larrain C, Kuo JS, Dempsey RJ. Enhanced expression of pentraxin-3 in glioblastoma cells correlates with increased invasion and IL8-VEGF signaling axis. Brain Res 2021;1776:147752. [PMID: 34906547 DOI: 10.1016/j.brainres.2021.147752] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/06/2021] [Revised: 11/13/2021] [Accepted: 12/07/2021] [Indexed: 02/07/2023]

Abstract

Glioblastoma (GB) is highly invasive and resistant to multimodal treatment partly due to distorted vasculature and exacerbated inflammation. The aggressiveness of brain tumors may be attributed to the dysregulated release of angiogenic and inflammatory factors. The glycoprotein pentraxin-3 (PTX3) is correlated with the severity of some cancers. However, the mechanism responsible for the invasive oncogenic role of PTX3 in GB malignancy remains unclear. In this study, we examined the role of PTX3 in GB growth, angiogenesis, and invasion using in vitro and in vivo GB models, proteomic profiling, molecular and biochemical approaches. Under in vitro conditions, PTX3 over-expression in U87 cells correlated with cell cycle progression, increased migratory potential, and proliferation under hypoxic conditions. Conditioned media containing PTX3 enhanced the angiogenic potential of endothelial cells. While silencing of PTX3 by siRNA decreased the proliferation, migration, and angiogenic potential of U87 cells in vitro. Importantly, PTX3 over-expression increased tumor growth, angiogenesis, and invasion in an orthotopic mouse model. Higher levels of PTX3 in these tumors were associated with the upregulation of inflammatory and angiogenic markers including interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF), but decreased levels of thrombospondin-1, an anti-angiogenic factor. Mechanistically, exogenous production of PTX3 triggered an IKK/NFκB signaling pathway that enhances the expression of the motility genes AHGEF7 and Rac1. Taken together, PTX3 expression is dysregulated in GB. PTX3 may augment invasion through enhanced angiogenesis in the GB microenvironment through the IL8-VEGF axis. Thus, PTX3 may represent a potential therapeutic target to mitigate the aggressive behavior of gliomas.

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de Pins B, Mendes T, Giralt A, Girault JA. The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases. Front Synaptic Neurosci 2021;13:749001. [PMID: 34690733 PMCID: PMC8527176 DOI: 10.3389/fnsyn.2021.749001] [Citation(s) in RCA: 27] [Impact Index Per Article: 6.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2021] [Accepted: 09/14/2021] [Indexed: 12/28/2022] Open

Abstract

Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts with extracellular matrix and other extracellular signals controlling adhesion and survival. Pyk2 shares some of FAK’s characteristics including recruitment of Src-family kinases after autophosphorylation, scaffolding by interacting with multiple partners, and activation of downstream signaling pathways. Pyk2, however, has the unique property to respond to increases in intracellular free Ca²⁺, which triggers its autophosphorylation following stimulation of various receptors including glutamate NMDA receptors. Pyk2 is dephosphorylated by the striatal-enriched phosphatase (STEP) that is highly expressed in the same neuronal populations. Pyk2 localization in neurons is dynamic, and altered following stimulation, with post-synaptic and nuclear enrichment. As a signaling protein Pyk2 is involved in multiple pathways resulting in sometimes opposing functions depending on experimental models. Thus Pyk2 has a dual role on neurites and dendritic spines. With Src family kinases Pyk2 participates in postsynaptic regulations including of NMDA receptors and is necessary for specific types of synaptic plasticity and spatial memory tasks. The diverse functions of Pyk2 are also illustrated by its role in pathology. Pyk2 is activated following epileptic seizures or ischemia-reperfusion and may contribute to the consequences of these insults whereas Pyk2 deficit may contribute to the hippocampal phenotype of Huntington’s disease. Pyk2 gene, PTK2B, is associated with the risk for late-onset Alzheimer’s disease. Studies of underlying mechanisms indicate a complex contribution with involvement in amyloid toxicity and tauopathy, combined with possible functional deficits in neurons and contribution in microglia. A role of Pyk2 has also been proposed in stress-induced depression and cocaine addiction. Pyk2 is also important for the mobility of astrocytes and glioblastoma cells. The implication of Pyk2 in various pathological conditions supports its potential interest for therapeutic interventions. This is possible through molecules inhibiting its activity or increasing it through inhibition of STEP or other means, depending on a precise evaluation of the balance between positive and negative consequences of Pyk2 actions.

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Singh S, Drude N, Blank L, Desai PB, Königs H, Rütten S, Langen K, Möller M, Mottaghy FM, Morgenroth A. Protease Responsive Nanogels for Transcytosis across the Blood-Brain Barrier and Intracellular Delivery of Radiopharmaceuticals to Brain Tumor Cells. Adv Healthc Mater 2021;10:e2100812. [PMID: 34490744 PMCID: PMC11468667 DOI: 10.1002/adhm.202100812] [Citation(s) in RCA: 20] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/26/2021] [Revised: 08/10/2021] [Indexed: 11/07/2022]

Alavian F, Ghasemi S. The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review. Curr Gene Ther 2021;21:230-245. [PMID: 33655831 DOI: 10.2174/1566523221666210224110454] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/21/2020] [Revised: 01/19/2021] [Accepted: 01/20/2021] [Indexed: 11/22/2022]

Aiello S, Casiraghi F. Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies? Cells 2021;10:cells10061390. [PMID: 34200030 PMCID: PMC8229068 DOI: 10.3390/cells10061390] [Citation(s) in RCA: 18] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/22/2021] [Revised: 05/26/2021] [Accepted: 05/28/2021] [Indexed: 02/06/2023] Open

Zhang X, Li M, Yin N, Zhang J. The Expression Regulation and Biological Function of Autotaxin. Cells 2021;10:cells10040939. [PMID: 33921676 PMCID: PMC8073485 DOI: 10.3390/cells10040939] [Citation(s) in RCA: 38] [Impact Index Per Article: 9.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2021] [Revised: 04/15/2021] [Accepted: 04/15/2021] [Indexed: 02/06/2023] Open

Brooks LJ, Clements MP, Burden JJ, Kocher D, Richards L, Devesa SC, Zakka L, Woodberry M, Ellis M, Jaunmuktane Z, Brandner S, Morrison G, Pollard SM, Dirks PB, Marguerat S, Parrinello S. The white matter is a pro-differentiative niche for glioblastoma. Nat Commun 2021;12:2184. [PMID: 33846316 PMCID: PMC8042097 DOI: 10.1038/s41467-021-22225-w] [Citation(s) in RCA: 52] [Impact Index Per Article: 13.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/12/2021] [Accepted: 02/23/2021] [Indexed: 02/02/2023] Open

Affiliation(s)

Lucy J Brooks Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Melanie P Clements Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Jemima J Burden MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
Daniela Kocher Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Luca Richards Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Sara Castro Devesa Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Leila Zakka Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Megan Woodberry Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Michael Ellis Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK
Zane Jaunmuktane Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, Queen Square, WC1N 3BG, London, UK Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
Sebastian Brandner Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, Queen Square, WC1N 3BG, London, UK Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
Gillian Morrison MRC Centre for Regenerative Medicine and Edinburgh Cancer Research UK Cancer Centre, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK
Steven M Pollard MRC Centre for Regenerative Medicine and Edinburgh Cancer Research UK Cancer Centre, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK
Peter B Dirks Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Departments of Surgery and Molecular Genetics, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
Samuel Marguerat MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK
Simona Parrinello Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK.

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Nimbalkar VP, Kruthika BS, Sravya P, Rao S, Sugur HS, Verma BK, Chickabasaviah YT, Arivazhagan A, Kondaiah P, Santosh V. Differential gene expression in peritumoral brain zone of glioblastoma: role of SERPINA3 in promoting invasion, stemness and radioresistance of glioma cells and association with poor patient prognosis and recurrence. J Neurooncol 2021;152:55-65. [PMID: 33389566 DOI: 10.1007/s11060-020-03685-4] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/10/2020] [Accepted: 12/18/2020] [Indexed: 10/22/2022]

Angelucci C, D’Alessio A, Sorrentino S, Biamonte F, Moscato U, Mangiola A, Sica G, Iacopino F. Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma. Int J Mol Sci 2021;22:ijms22041620. [PMID: 33562724 PMCID: PMC7914796 DOI: 10.3390/ijms22041620] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/21/2020] [Revised: 01/24/2021] [Accepted: 02/01/2021] [Indexed: 01/13/2023] Open

Affiliation(s)

Cristiana Angelucci Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Istologia ed Embriologia, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy; (C.A.); (S.S.); (G.S.); (F.I.)
Alessio D’Alessio Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Istologia ed Embriologia, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy; (C.A.); (S.S.); (G.S.); (F.I.) Correspondence:
Silvia Sorrentino Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Istologia ed Embriologia, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy; (C.A.); (S.S.); (G.S.); (F.I.)
Filippo Biamonte Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy; Dipartimento di Scienze di Laboratorio e Infettivologiche, Unità Operativa Complessa di Chimica, Biochimica e Biologia Molecolare, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy
Umberto Moscato Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Medicina del Lavoro e Igiene di Sanità Pubblica, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy; Dipartimento delle Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, 00168 Rome, Italy
Annunziato Mangiola Unità Operativa Complessa di Neurochirurgia, Ospedale Santo Spirito, 65124 Pescara, Italy; Dipartimento di Neuroscienze, Imaging e Scienze Cliniche, Università “G. D’Annunzio”, 66013 Chieti, Italy
Gigliola Sica Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Istologia ed Embriologia, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy; (C.A.); (S.S.); (G.S.); (F.I.)
Fortunata Iacopino Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Istologia ed Embriologia, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy; (C.A.); (S.S.); (G.S.); (F.I.)

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Robinson JW, Martin RM, Tsavachidis S, Howell AE, Relton CL, Armstrong GN, Bondy M, Zheng J, Kurian KM. Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility. Sci Rep 2021;11:2329. [PMID: 33504897 PMCID: PMC7840943 DOI: 10.1038/s41598-021-82169-5] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/26/2020] [Accepted: 01/07/2021] [Indexed: 12/29/2022] Open

SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation. Mol Neurobiol 2021;58:2634-2642. [PMID: 33481176 DOI: 10.1007/s12035-020-02240-6] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/06/2020] [Accepted: 11/25/2020] [Indexed: 12/15/2022]

Connor K, Murray DW, Jarzabek MA, Tran NL, White K, Dicker P, Sweeney KJ, O’Halloran PJ, MacCarthy B, Shiels LP, Lodi F, Lambrechts D, Sarkaria JN, Schiffelers RM, Symons M, Byrne AT. Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies. Cancers (Basel) 2020;12:cancers12123531. [PMID: 33256106 PMCID: PMC7761123 DOI: 10.3390/cancers12123531] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/26/2020] [Revised: 11/15/2020] [Accepted: 11/19/2020] [Indexed: 12/24/2022] Open

Abstract

Simple Summary

Glioblastoma (GBM) is an incurable disease with a 14-month average life-expectancy following diagnosis, and clinical management has not improved in four decades. GBM mortality is due to rapid tumour growth and invasion into surrounding normal brain. Invasive cells make complete surgical removal of the tumour impossible, and result in disease relapse. Thus, it is imperative that any new treatment strategy takes these invading cells into consideration. Bevacizumab (Bev), which prevents the formation of new blood vessels, is an FDA approved therapy, but it has failed to increase overall survival in GBM and has even been shown to increase tumour invasion in some cases. Complementary anti-invasive therapies are therefore urgently required to enhance bevacizumab efficacy. We have identified βPIX/COOL-1, a RhoGEF protein which plays an important role in GBM cell invasion and angiogenesis and could be a useful target in this setting.

Abstract

Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators of key components in Bev resistance pathways, GBM and Bev-induced invasion. To identify GEFs with enhanced mRNA expression in the leading edge of GBM tumours, a cohort of GEFs was assessed using a clinical dataset. The GEF βPix/COOL-1 was identified, and the functional effect of gene depletion assessed using 3D-boyden chamber, proliferation, and colony formation assays in GBM cells. Anti-angiogenic effects were assessed in endothelial cells using tube formation and wound healing assays. In vivo effects of βPix/COOL-1-siRNA delivered via RGD-Nanoparticle in combination with Bev was studied in an invasive model of GBM. We found that siRNA-mediated knockdown of βPix/COOL-1 in vitro decreased cell invasion, proliferation and increased apoptosis in GBM cell lines. Moreover βPix/COOL-1 mediated endothelial cell migration in vitro. Mice treated with βPix/COOL-1 siRNA-loaded RGD-Nanoparticle and Bev demonstrated a trend towards improved median survival compared with Bev monotherapy. Our hypothesis generating study suggests that the RhoGEF βPix/COOL-1 may represent a target of vulnerability in GBM, in particular to improve Bev efficacy.

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Affiliation(s)

Kate Connor Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.)
David W. Murray Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.)
Monika A. Jarzabek Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.)
Nhan L. Tran Department of Cancer Biology and Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85054, USA;
Kieron White Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.)
Patrick Dicker Epidemiology & Public Health, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
Kieron J. Sweeney Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.) National Neurosurgical Department, Beaumont Hospital, Dublin 9, Ireland
Philip J. O’Halloran Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.) National Neurosurgical Department, Beaumont Hospital, Dublin 9, Ireland
Brian MacCarthy Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.)
Liam P. Shiels Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.)
Francesca Lodi Center for Cancer Biology, Laboratory for Translational Genetics, Vlaams Instituut voor Biotechnologie (VIB), B-3000 Leuven, Belgium; (F.L.); (D.L.)
Diether Lambrechts Center for Cancer Biology, Laboratory for Translational Genetics, Vlaams Instituut voor Biotechnologie (VIB), B-3000 Leuven, Belgium; (F.L.); (D.L.)
Jann N. Sarkaria Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA;
Raymond M. Schiffelers Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 100 3584 Utrecht, The Netherlands;
Marc Symons Department of Oncology & Cell Biology, Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, NY 11030, USA;
Annette T. Byrne Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; (K.C.); (D.W.M.); (M.A.J.); (K.W.); (K.J.S.); (P.J.O.); (B.M.); (L.P.S.) Correspondence: ; Tel.: +353-1-402-8673

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Mutharasu G, Murugesan A, Konda Mani S, Yli-Harja O, Kandhavelu M. Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication. J Biomol Struct Dyn 2020;40:2586-2599. [PMID: 33140689 DOI: 10.1080/07391102.2020.1841029] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/06/2023]

Vitovcova B, Skarkova V, Rudolf K, Rudolf E. Biology of Glioblastoma Multiforme-Exploration of Mitotic Catastrophe as a Potential Treatment Modality. Int J Mol Sci 2020;21:ijms21155324. [PMID: 32727112 PMCID: PMC7432846 DOI: 10.3390/ijms21155324] [Citation(s) in RCA: 23] [Impact Index Per Article: 4.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2020] [Revised: 07/22/2020] [Accepted: 07/25/2020] [Indexed: 12/23/2022] Open

Signaling Determinants of Glioma Cell Invasion. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2020;1202:129-149. [PMID: 32034712 DOI: 10.1007/978-3-030-30651-9_7] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/27/2022]

Tang Z, Gillatt D, Rowe E, Koupparis A, Holly JM, Perks CM. IGFBP-2 acts as a tumour suppressor and plays a role in determining chemosensitivity in bladder cancer cells. Oncotarget 2019;10:7043-7057. [PMID: 31903164 PMCID: PMC6925026 DOI: 10.18632/oncotarget.27355] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2019] [Accepted: 10/21/2019] [Indexed: 12/13/2022] Open

PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis. Sci Rep 2019;9:16922. [PMID: 31729427 PMCID: PMC6858377 DOI: 10.1038/s41598-019-53097-2] [Citation(s) in RCA: 25] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/14/2019] [Accepted: 10/23/2019] [Indexed: 11/09/2022] Open

Identification of SERPINE1 as a Regulator of Glioblastoma Cell Dispersal with Transcriptome Profiling. Cancers (Basel) 2019;11:cancers11111651. [PMID: 31731490 PMCID: PMC6896086 DOI: 10.3390/cancers11111651] [Citation(s) in RCA: 43] [Impact Index Per Article: 7.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2019] [Revised: 10/18/2019] [Accepted: 10/21/2019] [Indexed: 12/23/2022] Open

Dhuriya YK, Sharma D, Naik AA. Cellular demolition: Proteins as molecular players of programmed cell death. Int J Biol Macromol 2019;138:492-503. [PMID: 31330212 DOI: 10.1016/j.ijbiomac.2019.07.113] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/23/2019] [Revised: 06/25/2019] [Accepted: 07/19/2019] [Indexed: 12/11/2022]

Pleotropic Roles of Autotaxin in the Nervous System Present Opportunities for the Development of Novel Therapeutics for Neurological Diseases. Mol Neurobiol 2019;57:372-392. [PMID: 31364025 DOI: 10.1007/s12035-019-01719-1] [Citation(s) in RCA: 34] [Impact Index Per Article: 5.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2019] [Accepted: 07/23/2019] [Indexed: 12/23/2022]

Abstract

Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a phosphodiesterase and a phospholipase. The majority of its biological effects have been associated with its ability to liberate lysophosphatidic acid (LPA) from its substrate, lysophosphatidylcholine (LPC). LPA has diverse pleiotropic effects in the central nervous system (CNS) and other tissues via the activation of a family of six cognate G protein-coupled receptors. These LPA receptors (LPARs) are expressed in some combination in all known cell types in the CNS where they mediate such fundamental cellular processes as proliferation, differentiation, migration, chronic inflammation, and cytoskeletal organization. As a result, dysregulation of LPA content may contribute to many CNS and PNS disorders such as chronic inflammatory or neuropathic pain, glioblastoma multiforme (GBM), hemorrhagic hydrocephalus, schizophrenia, multiple sclerosis, Alzheimer's disease, metabolic syndrome-induced brain damage, traumatic brain injury, hepatic encephalopathy-induced cerebral edema, macular edema, major depressive disorder, stress-induced psychiatric disorder, alcohol-induced brain damage, HIV-induced brain injury, pruritus, and peripheral nerve injury. ATX activity is now known to be the primary biological source of this bioactive signaling lipid, and as such, represents a potentially high-value drug target. There is currently one ATX inhibitor entering phase III clinical trials, with several additional preclinical compounds under investigation. This review discusses the physiological and pathological significance of the ATX-LPA-LPA receptor signaling axis and summarizes the evidence for targeting this pathway for the treatment of CNS diseases.

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Cesarini V, Silvestris DA, Tassinari V, Tomaselli S, Alon S, Eisenberg E, Locatelli F, Gallo A. ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion. Nucleic Acids Res 2019;46:2045-2059. [PMID: 29267965 PMCID: PMC5829642 DOI: 10.1093/nar/gkx1257] [Citation(s) in RCA: 94] [Impact Index Per Article: 15.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/12/2017] [Accepted: 12/05/2017] [Indexed: 12/26/2022] Open

Kim S, Choi JY, Seok HJ, Park MJ, Chung HY, Bae IH. miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2. MOLECULAR THERAPY. NUCLEIC ACIDS 2019;17:245-255. [PMID: 31272074 PMCID: PMC6610659 DOI: 10.1016/j.omtn.2019.05.022] [Citation(s) in RCA: 21] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/18/2018] [Revised: 05/24/2019] [Accepted: 05/24/2019] [Indexed: 12/11/2022]

Alshabi AM, Vastrad B, Shaikh IA, Vastrad C. Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis. Biomolecules 2019;9:biom9050201. [PMID: 31137733 PMCID: PMC6571969 DOI: 10.3390/biom9050201] [Citation(s) in RCA: 29] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2019] [Revised: 05/17/2019] [Accepted: 05/23/2019] [Indexed: 02/07/2023] Open

Abstract

The present study aimed to investigate the molecular mechanisms underlying glioblastoma multiform (GBM) and its biomarkers. The differentially expressed genes (DEGs) were diagnosed using the limma software package. The ToppGene (ToppFun) was used to perform pathway and Gene Ontology (GO) enrichment analysis of the DEGs. Protein-protein interaction (PPI) networks, extracted modules, miRNA-target genes regulatory network and TF-target genes regulatory network were used to obtain insight into the actions of DEGs. Survival analysis for DEGs was carried out. A total of 590 DEGs, including 243 up regulated and 347 down regulated genes, were diagnosed between scrambled shRNA expression and Lin7A knock down. The up-regulated genes were enriched in ribosome, mitochondrial translation termination, translation, and peptide biosynthetic process. The down-regulated genes were enriched in focal adhesion, VEGFR3 signaling in lymphatic endothelium, extracellular matrix organization, and extracellular matrix. The current study screened the genes in the PPI network, extracted modules, miRNA-target genes regulatory network, and TF-target genes regulatory network with higher degrees as hub genes, which included NPM1, CUL4A, YIPF1, SHC1, AKT1, VLDLR, RPL14, P3H2, DTNA, FAM126B, RPL34, and MYL5. Survival analysis indicated that the high expression of RPL36A and MRPL35 were predicting longer survival of GBM, while high expression of AP1S1 and AKAP12 were predicting shorter survival of GBM. High expression of RPL36A and AP1S1 were associated with pathogenesis of GBM, while low expression of ALPL was associated with pathogenesis of GBM. In conclusion, the current study diagnosed DEGs between scrambled shRNA expression and Lin7A knock down samples, which could improve our understanding of the molecular mechanisms in the progression of GBM, and these crucial as well as new diagnostic markers might be used as therapeutic targets for GBM.

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Role of autotaxin in cancer stem cells. Cancer Metastasis Rev 2019;37:509-518. [PMID: 29926310 DOI: 10.1007/s10555-018-9745-x] [Citation(s) in RCA: 26] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]