Endoscopic full thickness resection for gastric tumors originating from muscularis propria

Table 1 Descriptive summary of all studies

Ref. andlocation	Study type	Inclusion criterion	Exclusion criterion	No. of subjects	No. of lesions	Tumor location	Mean size of lesion (range) (cm)	Mean procedure time (range) (min)	Complications	Success rate (%)	Follow up
Ye et al[11], 2014 China	Retrospective Single Centre	(1) CT/EUS confirmation of MP origin (2) No extraluminal growth	(1) Size > 3.5 cm (2) Coagulation disorders (3) Unfit for GA (4) High risk features on EUS (irregular border, cystic spaces, ulceration, echogenic foci, heterogeneity)	51	51	(1) Fundus = 22 (2) Corpus = 28 (3) Antrum = 1	2.4 (1.3-3.5)	52 (30-125)	None	98	(1) Surveillance endoscopy for healing at 1, 3 and 6 mo PP (2) For GIST = Endoscopy/EUS/abdominal ultrasound/CT/chest radiography every 12 mo, indefinitely
Schlag et al[15], 2013 Germany	Retrospective Single Centre	(1) Age > 18 yr (2) Confirmed SET originating from MP on EUS	(1) Size > 3.0 cm (2) ASA class 4 or 5 (3) Coagulopathy (4) Pregnancy	EFTR group = 6	6	(1) Corpus = 4 (2) Antrum = 1 (3) Cardia = 1	1.3 (0.7-2.0)	37.3 (26-45)	None	83.3	(1) Telephone interview or outpatient visit at 1 mo PP (2) Endoscopy at 3 mo PP
				Lap group = 5	5	(1) Fundus = 1 (2) Corpus = 4	1.88 (0.8-2.6)	55 (30-95)	None	80
Feng et al[16], 2014 China	Retrospective Single Centre	(1) MP originating tumor confirmed on EUS or CT if size > 2.0 cm	(1) Size > 5.0 cm (2) Coagulopathy (3) Patients not suitable for GA	48	52	(1) Fundus = 40 (2) Corpus = 7 (3) Antrum = 1	1.59 (0.50-4.80)	59.72 (30-270)	(1) Abdominal distension = 5	100	(1) Endoscopy at 2, 6, 12 and 24 mo PP
Guo et al[17], 2015 China	Retrospective Single Centre	(1) CT and EUS confirming origin of tumor from MP	(1) Size > 2.0 cm (2) Enlarged lymph nodes (3) Malignant disease	23	23	(1) Fundus = 11 (2) Corpus = 9 (3) Antrum = 3	1.21 (0.6-2.0)	(1) Mean ETFR time = 40.5 (16-104) (2) Mean closure time = 4.9 (2-12)	(1) Loocalised peritonitis = 2 (managed conservatively) (2) Post op fever = 4	100	(1) Endoscopy at 1 wk, 1 and 6 mo PP
Wu et al[18], 2015 China	Retrospective analysis of clincal control study	(1) Single tumor (2) Absence of metastasis	(1) Size > 5.5 cm	EFTR group = 50	50	(1) Fundus = 14 (2) Corpus = 23 (3) Antrum = 13	3.4 (2.5-5.0)	85 (55-155)	None	100	(1) Endoscopy at 1 mo PP
				Lap group = 42	42	(1) Fundus = 8 (2) Corpus = 19 (3) Antrum = 15	3.8 (3.0-5.0)	88 (45-215)	(1) Gastroparesis = 2 (managed conservatively)	93
Zhou et al[19], 2011 China	Retrospective Single Centre	(1) MP originating tumors confirmed on EUS	(1) Size > 5.0 cm (2) Patients not fit for GA (3) Known abdominal adhesions	26	26	(1) Fundus = 12 (2) Corpus = 14	2.8 (1.2-4.5)	105 (60-145)	None	100	(1) Endoscopy at 2, 4 and 6 mo PP and then every 6 mo (2) EUS or CT scan was performed if tumor residual or recurrence was suspected

GA: General anesthesia; MP: Muscularis propria; PP: Post procedure; SET: Subepithelial tumor; EFTR: Endoscopic full thickness resection; Lap: Laparoscopic; CT: Computed tomography; EUS: Endoscopic ultrasonography; GIST: Gastrointestinal stromal tumors; ASA: American society of anesthesiologists.