Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature

Table 1 Summary of the literature review of squamous cell lung carcinoma with pancreatic metastasis

Ref.	Yr	Setting	Number	Age in yr	Sex	Symptoms	Imaging	Endoscopy +/- FNA	Diagnostic means	Treatment	Follow-up	Overall survival	Status at time of publication
Zhou et al[29]	2020	China	1	63	M	Epigastric pain with jaundice	Hyperintense mass measuring 4.5 cm in the pancreatic head	No	Surgery of the pancreatic mass	Whipple procedure	UNK	UNK	UNK
Stoupis et al[30]	2020	Greece	1	60	F	Fatigue, cough and hemoptysis, loss of appetite and 10-kg weight loss	Increased 2-deoxy-2-[F-18] fluoro-D-glucose uptake in the right lung and pancreatic tail	Yes	EUS-FNB of the pancreatic mass using a 22-gauge needle	7 cycles of anti-PD-L1 antibody pembrolizumab	UNK	UNK	Alive
Wang et al[4]	2020	China	1	57	M	Asymptomatic	PET-CT scan showed pancreatic metastasis (1 yr after diagnosis of squamous cell lung carcinoma)	No	Laparoscopic radical pancreatic body tail and splenectomy	4 cycles of gemcitabine (1000 mg/m2) plus cisplatin (65 mg/m2) due to progression of the lung mass and the appearance of a tumor in the head of the pancreas. He received 3 cycles of pembrolizumab (2 mg/kg)	1 yr	21.1 mo	Dead
Ishikawa et al[31]	2017	Canada	1	70	M	Abdominal pain and weight loss	3.8 cm hypodense mass in the pancreatic body with lymphadenopathy in the left supraclavicular region and a 3-cm lung mass posterior to the left main stem bronchus	Yes	EUS-FNB of these two lesions with a 25-G needle	Palliative chemotherapy	UNK	UNK	UNK
Fujji et al[32]	2015	Japan	1	70	M	High fever and jaundice 6 mo after left lung inferior lobe resection	Low contrast-enhanced mass with relatively clear border and a size of 40 mm × 33 mm in the head of the pancreas	Yes	FNA via a transgastric approach with linear EUS	5 cycles of carboplatin plus weekly paclitaxel	226 d	UNK	Dead
Dewanwala et al[33]	2012	United States	1	65	M	Dyspnea and recurrent cough	Left hilar mass with an incidental well-defined mass involving the uncinate process of the pancreas measuring 3.7 cm × 2.2 cm	Yes	Pylorus-preserving pancreaticoduodenectomy	Carboplatin plus gemcitabine and completed 5 cycles	17 mo	UNK	Dead
Layfield et al[34]	2010	United States	1	UNK	M	UNK	UNK	Yes	EUS + FNA of the pancreatic mass	UNK	UNK	UNK	UNK
Liratzopoulos et al[23]	2006	Greece	1	53	M	Jaundice, loss of appetite, nausea and mild abdominal pain	CT scan: carcinoma of the lower lobe of the right lung, a tumor in the pancreatic head measuring 4.0 cm × 4.1 cm × 3.5 cm, dilatation of the biliary tract and multiple enlarged lymph nodes in the cervical area, the mediastinum and the abdomen	No	A percutaneous FNA of the pancreatic tumor under CT guidance	Cholecystojejunostomy + dissection of lymph node near the pancreas	19 d	UNK	Dead
Mesa et al[35]	2004	United States	2	UNK	UNK	UNK	Mass in the head of the pancreas measuring 3.6 cm and a lung tumor	Yes	EUS-FNA of the pancreatic mass	UNK	UNK	UNK	UNK
Volkan et al[36]	2004	United States	5 of 109 autopsy cases	UNK	UNK	UNK	UNK	UNK	Autopsy	UNK	UNK	UNK	Dead
Tetsuya et al[37]	2003	Japan	1	69	M	Jaundice	Lung tumor with hilar and mediastinal lymph node swelling and solitary pancreatic head tumor measuring 3 cm	No	Autopsy	Endoscopic nasobiliary drainage and stent drainage therapy prior to chemotherapy using gemcitabine	4 mo	UNK	Dead
Moazzam et al[38]	2002	United States	1	54	M	Anorexia, abdominal pain and jaundice	Mass in right upper lung lobe and mass in the head of pancreas	No	Biopsy of the right upper lobe lung mass	Biliary drainage + carboplatin and paclitaxel	UNK	UNK	Alive: good clinical and radiographic response
Nakamura et al[11]	2001	Japan	3 of 103 autopsy cases	UNK	UNK	UNK	UNK	UNK	Autopsy	UNK	UNK	UNK	Dead
Matsukuma et al[39]	1997	Japan	3	55	M	UNK	UNK	No	Autopsy	UNK	UNK	UNK	Dead
				64	M
				58	M

CT: Computed tomography; EUS: Endoscopic ultrasound; F: Female; FNA: Fine-needle aspiration; FNB: Fine-needle biopsy; M: Male; PD-L1: Programmed death ligand 1; PET: Positron emission tomography; UNK: Unknown.