Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy

Figure 1 Mucosal cutting biopsy of a submucosal tumor with intraluminal growth in the lesser curvature of the corpus. A: The mucosal incision was made by a needle-knife after an injection of saline; B: Biopsy specimen obtained from the tumor using biopsy forceps under direct observation; C: The incision was closed with hemoclips; D: Histological examination of the biopsied specimen showing a spindle cell without mitotic figures (HE); E: Immunohistochemical staining was positive for desmin. This lesion was diagnosed histologically as a leiomyoma.

Figure 2 Endoscopic ultrasonography-guided fine-needle aspiration biopsy of a gastrointestinal stromal tumor with extraluminal growth. A: EUS-FNAB of a hypoechoic lesion in the muscularis propria layer showing extraluminal growth; B: Histological finding showing spindle cells in the EUS-FNAB specimen (HE); C: Immunohistochemical staining is positive for c-kit. EUS-FNAB: Endoscopic ultrasonography-guided fine-needle aspiration biopsy.