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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Sep 16, 2017; 9(9): 471-479
Published online Sep 16, 2017. doi: 10.4253/wjge.v9.i9.471
Published online Sep 16, 2017. doi: 10.4253/wjge.v9.i9.471
Colonoscopy quality with Entonox®vs intravenous conscious sedation: 18608 colonoscopy retrospective study
Alexander R Robertson, Colin L Noble, Department of Gastroenterology, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
Nicholas A Kennedy, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
Nicholas A Kennedy, Department of Gastroenterology, University of Exeter, Exeter EX4 4QJ, United Kingdom
James A Robertson, School of Life Sciences, University of Nottingham, Nottingham NJ7 2UH, United Kingdom
Nicholas I Church, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom
Author contributions: Robertson AR, Kennedy NA and Noble CL designed the research; Robertson AR, Kennedy NA and Robertson JA were involved in data analysis and writing of the draft manuscript; Church NI and Noble CL critically revised the manuscript for important intellectual content.
Institutional review board statement: This study was performed as a service evaluation and in accordance with local and UK policy, there was no requirement for an ethics committee review.
Informed consent statement: Consent was not obtained but the presented data are anonymised and risk of identification is low.
Conflict-of-interest statement: None declared.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at colin.noble@nhslothian.scot.nhs.uk.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Colin L Noble, MBChB, MD, MRCP, Consultant Gastroenterologist, Department of Gastroenterology, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, United Kingdom. colin.noble@nhslothian.scot.nhs.uk
Telephone: +44-131-5371000
Received: March 26, 2017
Peer-review started: March 28, 2017
First decision: June 30, 2017
Revised: July 10, 2017
Accepted: August 15, 2017
Article in press: August 16, 2017
Published online: September 16, 2017
Peer-review started: March 28, 2017
First decision: June 30, 2017
Revised: July 10, 2017
Accepted: August 15, 2017
Article in press: August 16, 2017
Published online: September 16, 2017
Core Tip
Core tip: Previous studies have shown that colonoscopies performed with Entonox® gas are not associated with more patient discomfort, or lower caecal intubation rates, than those performed with intravenous conscious sedation. We have completed the largest and most comprehensive real-world retrospective study of Entonox use in colonoscopy. In particular, we compare colonoscopy quality with Entonox against intravenous conscious sedation using midazolam plus opioid. This study shows that Entonox is not associated with lower colonoscopy quality when compared to intravenous conscious sedation. Based on the results of this study, Entonox remains an attractive option for colonoscopy analgesia and sedation.