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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 10, 2015; 7(16): 1197-1207
Published online Nov 10, 2015. doi: 10.4253/wjge.v7.i16.1197
Published online Nov 10, 2015. doi: 10.4253/wjge.v7.i16.1197
Pancreatic insulinomas: Laparoscopic management
Pantelis T Antonakis, Department of Surgery, Athens Euroclinic, 11521 Athens, Greece
Hutan Ashrafian, Alberto Martinez-Isla, Department of Upper GI Surgery, Northwick Park and St Mark's Hospital, North West London Hospitals NHS Trust, London HA1 3UJ, United Kingdom
Hutan Ashrafian, the Department of Surgery and Cancer, Imperial College London, St Mary’s Hospital, London W2 1NY, United Kingdom
Author contributions: Martinez-Isla A designed the study concept, drafted the manuscript, and was the lead laparoscopic surgeon; Antonakis PT and Ashrafian H researched and drafted the final manuscript.
Conflict-of-interest statement: No conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alberto Martinez-Isla, FRCS, Consultant Surgeon, Department of Upper GI Surgery, Northwick Park Hospital, North West London Hospitals NHS Trust, Watford Road, Harrow, Middlesex, London HA1 3UJ, United Kingdom. a.isla@imperial.ac.uk
Telephone: +44-208-4532619 Fax: +44-208-2425912
Received: April 28, 2015
Peer-review started: May 6, 2015
First decision: June 2, 2015
Revised: June 22, 2015
Accepted: August 25, 2015
Article in press: November 7, 2015
Published online: November 10, 2015
Peer-review started: May 6, 2015
First decision: June 2, 2015
Revised: June 22, 2015
Accepted: August 25, 2015
Article in press: November 7, 2015
Published online: November 10, 2015
Core Tip
Core tip: Insulinomas have always fascinated physicians and surgeons alike, due to the difficulties in: (1) diagnosing them; (2) obtaining accurate preoperative and intraoperative localization; and (3) actually performing the operation safely and effectively. Laparoscopy stands out in the current literature as the approach of choice, and is employed for virtually all benign insulinomas. Enucleations for insulinomas in the head and body, as well as distal pancreatectomies for lesions in the body and tail of the pancreas, have been shown to be safe and effective in the current series. Laparoscopic intraoperative ultrasound localization has emerged as a standard adjunct to these procedures.