Shu J, Yang J. Pediatric endoscopic retrograde cholangiopancreatography: A systematic review of indications, technical success, adverse events, and complication prevention. World J Gastrointest Endosc 2026; 18(9): 125072 [DOI: 10.4253/wjge.125072]
Corresponding Author of This Article
Jun Yang, Associate Professor, Department of Gastrointestinal Surgery, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, No. 100 Hongkong Road, Jiang’an District, Wuhan 430016, Hubei Province, China. yangjun@zgwhfe.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
research-article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Shu J, Yang J. Pediatric endoscopic retrograde cholangiopancreatography: A systematic review of indications, technical success, adverse events, and complication prevention. World J Gastrointest Endosc 2026; 18(9): 125072 [DOI: 10.4253/wjge.125072]
World J Gastrointest Endosc. Sep 16, 2026; 18(9): 125072 Published online Sep 16, 2026. doi: 10.4253/wjge.125072
Pediatric endoscopic retrograde cholangiopancreatography: A systematic review of indications, technical success, adverse events, and complication prevention
Jun Shu, Jun Yang
Jun Shu, Jun Yang, Department of Gastrointestinal Surgery, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, Hubei Province, China
Co-corresponding authors: Jun Shu and Jun Yang.
Author contributions: Shu J conceived the review topic, designed the study framework, coordinated the project, developed the literature search strategy, screened and interpreted the relevant literature, and drafted the manuscript; Yang J supervised the project, provided overall academic and clinical guidance, reviewed the manuscript critically for important intellectual content, and approved the final version for submission; Shu J and Yang J contributed to the development of the review, revised the manuscript, and approved the final version for publication as co-corresponding authors.
AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.
Conflict-of-interest statement: Both authors declare no conflict of interest in publishing the manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Jun Yang, Associate Professor, Department of Gastrointestinal Surgery, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, No. 100 Hongkong Road, Jiang’an District, Wuhan 430016, Hubei Province, China. yangjun@zgwhfe.com
Received: July 1, 2026 Revised: July 8, 2026 Accepted: August 5, 2026 Published online: September 16, 2026 Processing time: 73 Days and 18.5 Hours
Core Tip
Core Tip: This systematic review synthesizes recent evidence on pediatric endoscopic retrograde cholangiopancreatography from a finalized 128-study dataset. Rather than pooling event rates across incompatible definitions, it emphasizes endpoint-specific denominators. Contemporary studies show high study-level technical success (median 94.7%), whereas post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP; median 5.2%) remains the principal procedure-related adverse event. The review highlights persistent reporting gaps and the need for standardized pediatric definitions, prospective multicenter registries, and pediatric-specific PEP prevention trials, including those of rectal nonsteroidal anti-inflammatory drugs and pancreatic-duct stents.
