Minireviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jul 16, 2025; 17(7): 107746
Published online Jul 16, 2025. doi: 10.4253/wjge.v17.i7.107746
Prevention and treatment of recurrence after endoscopic resection of large non-pedunculated colorectal polyps
Samantha Pang, Pedram Tavakoli, Neal Shahidi
Samantha Pang, Pedram Tavakoli, Department of Gastroenterology, St. Paul's Hospital, Vancouver V6Z2K5, Canada
Neal Shahidi, Department of Medicine, University of British Columbia, Vancouver V6Z2K5, Canada
Author contributions: Pang S created the manuscript; Tavakoli P and Shahidi N revised the manuscript for important intellectual content; all authors have read and approved the final manuscript.
Conflict-of-interest statement: Shahidi N received a speaker’s honorarium from Pharmascience, Boston Scientific, and Takeda Pharmaceuticals. Pang S and Tavakoli P have no conflict of interests to report.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Neal Shahidi, MD, PhD, Assistant Professor, Department of Medicine, University of British Columbia, 770-1190 Hornby Street, Vancouver V6Z2K5, Canada. nealshahidi@gmail.com
Received: March 30, 2025
Revised: April 17, 2025
Accepted: May 21, 2025
Published online: July 16, 2025
Processing time: 103 Days and 4.3 Hours
Core Tip

Core Tip: Endoscopic resection techniques are the recommended treatment strategy for most large non-pedunculated colorectal polyps, with endoscopic mucosal resection as a predominant resection modality. However, recurrence has historically occurred in 15%-20% of lesions. Margin thermal ablation and pre-resection margin marking can effectively mitigate recurrence. Moreover, effective recurrence management techniques can reduce the need for surgery. Herein, we appraise existing evidence on the frequency of recurrence, reasonings behind recurrence formation, as well as recurrence mitigating and management strategies.