Towards precision care: Fluctuations in albumin and fibrinogen as noninvasive predictors of endoscopic outcomes in Crohn’s disease

doi:10.4253/wjge.v17.i5.105365

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May 16, 2025 (publication date) through May 12, 2025

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. May 16, 2025; 17(5): 105365
Published online May 16, 2025. doi: 10.4253/wjge.v17.i5.105365

Towards precision care: Fluctuations in albumin and fibrinogen as noninvasive predictors of endoscopic outcomes in Crohn’s disease

Ana-Maria Singeap, Horia Minea, Remus Stafie, Carol Stanciu, Anca Trifan

Ana-Maria Singeap, Horia Minea, Remus Stafie, Carol Stanciu, Anca Trifan, Department of Gastroenterology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, Romania

Ana-Maria Singeap, Horia Minea, Remus Stafie, Carol Stanciu, Anca Trifan, Institute of Gastroenterology and Hepatology, “St. Spiridon” University Hospital, Iasi 700111, Romania

Author contributions: Singeap AM designed the editorial; Minea H and Stafie R wrote the paper; Stanciu C and Trifan A revised the paper for important intellectual content; and all authors thoroughly reviewed and endorsed the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Horia Minea, MD, PhD, Assistant Professor, Department of Gastroenterology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, Iasi 700115, Romania. horia.minea@yahoo.com

Received: January 20, 2025
Revised: March 29, 2025
Accepted: April 17, 2025
Published online: May 16, 2025
Processing time: 112 Days and 18 Hours

Core Tip

Core Tip: This article highlights the significance of a study by Wang et al, which identifies fluctuations in albumin and fibrinogen as noninvasive biomarkers for predicting endoscopic improvement in Crohn’s disease. By introducing a validated nomogram model with high predictive accuracy, the study offers a practical, patient-centered alternative to invasive monitoring methods. These findings underscore the potential of biomarker-driven decision-making to refine therapeutic strategies, enhance patient care, and advance precision medicine in Crohn’s disease management.