Prospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. May 16, 2025; 17(5): 101322
Published online May 16, 2025. doi: 10.4253/wjge.v17.i5.101322
Colon capsule endoscopy is an effective filter test for colonic polyp surveillance
Serhiy Semenov, Mohd Syafiq Ismail, Sandeep Sihag, Thilagaraj Manoharan, Phyllis Reilly, Gerard Boran, Barbara Ryan, Niall Breslin, Anthony O’Connor, Sarah O’Donnell, Deirdre McNamara
Serhiy Semenov, Mohd Syafiq Ismail, Sandeep Sihag, Deirdre McNamara, Trinity Academic Gastroenterology Group, School of Medicine - Trinity College Dublin, Dublin D2, Ireland
Serhiy Semenov, Mohd Syafiq Ismail, Sandeep Sihag, Thilagaraj Manoharan, Barbara Ryan, Niall Breslin, Anthony O’Connor, Sarah O’Donnell, Deirdre McNamara, Department of Gastroenterology, Tallaght University Hospital, Dublin D24, Ireland
Phyllis Reilly, Gerard Boran, Department of Clinical Chemistry, Tallaght University Hospital, Dublin D24, Ireland
Author contributions: Semenov S and McNamara D designed the research study and wrote/edited the manuscript. Semenov S, Ismail MS, Sihag S, Manoharan T and Reilly P performed the research and assisted in data generation. Boran G, Ryan B, Breslin N, O’Connor A, O’Donnell S offered expert opinion and assisted in carrying out the research in relevant departments.
Institutional review board statement: This study was approved by the Medical Ethics Committee of St James’s Hospital/Tallaght University Hospital Research, approval No. 2019-03 List 11(04).
Clinical trial registration statement: This form is not applicable as this study is not a clinical trial.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Serhiy Semenov, MRCP, Trinity Academic Gastroenterology Group, School of Medicine - Trinity College Dublin, Dublin 2, Dublin D2, Ireland. semenovs@tcd.ie
Received: September 10, 2024
Revised: February 26, 2025
Accepted: April 11, 2025
Published online: May 16, 2025
Processing time: 243 Days and 9.3 Hours
Core Tip

Core Tip: This is a prospective study uniquely combining colon capsule endoscopy and the faecal immunochemical test as potential filter tests for colonic polyp surveillance patients. Given the burden of surveillance on limited endoscopy resources, we believe surveillance practice can be more balanced, in particular with respect to low risk patients who are less likely to need an invasive test and polypectomy. Our study shows that more than 50% percent of patients can avoid a full colonoscopy and that colon capsule endoscopy in particular can serve as an alternative to colonoscopy in surveillance. In contrast, faecal immunochemical test on its own underperformed in this cohort.