Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Feb 16, 2024; 16(2): 64-71
Published online Feb 16, 2024. doi: 10.4253/wjge.v16.i2.64
Retrospective analysis of discordant results between histology and other clinical diagnostic tests on helicobacter pylori infection
Xiaohua Qi, Kevin Kuan, Tony El Jabbour, Yungtai Lo, Qiang Liu, Yanan Fang
Xiaohua Qi, Kevin Kuan, Qiang Liu, Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10467, United States
Tony El Jabbour, Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY 10467, United States
Yungtai Lo, Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, United States
Yanan Fang, Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10467, United States
Co-first authors: Xiaohua Qi and Kevin Kuan.
Author contributions: Qi X and Kuan K contributed equally to this work; Fang Y and Liu Q designed the research study; Qi X and Kuan K performed the data extraction; Kuan K, Qi X, Jabbour T, Liu Y, and Fang Y performed the data analysis and interpretation of the results; Fang Y, Kuan K, and Qi X wrote the manuscript, Lo Y is a Biostatistics professor and performed the statistical analysis; Fang Y, Kuan K and Qi X revised the manuscript; and all authors read and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Albert Einstein College of Medicine Institutional Review Board (IRB No: 2016-6957).
Informed consent statement: This is a retrospective study with a focus on quality assurance (QA). The institutional review board (IRB) granted a waiver of consent.
Conflict-of-interest statement: All the authors declare no conflicts of interest for this article.
Data sharing statement: De-identified dataset available from the corresponding author at Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yanan Fang, MD, PhD, Associate Professor, Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, 111 East 210th St., Bronx, NY 10467, United States.
Received: November 14, 2023
Peer-review started: November 14, 2023
First decision: December 5, 2023
Revised: December 24, 2024
Accepted: January 11, 2024
Article in press: January 11, 2024
Published online: February 16, 2024
Core Tip

Core Tip: The concordance between histopathology and rapid urease test (CLO test) or stool antigen test (SA) for detecting Helicobacter pylori (H. pylori) detection is excellent. The agreement between histology and H. pylori culture is good. Concordance between histopathology and other tests shows no significant differences based on the number of biopsy fragments. Occasionally, there are rare cases where histology is negative for H. pylori, while the CLO test or SA is positive. The causes of such discrepancies may be multifactorial, necessitating a separate analysis for each case with clinical correlation. Most of these cases were subsequently treated for H. pylori infection.