Retrospective Cohort Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Feb 16, 2019; 11(2): 124-132
Published online Feb 16, 2019. doi: 10.4253/wjge.v11.i2.124
No significant difference in clinically relevant findings between Pillcam® SB3 and Pillcam® SB2 capsules in a United States veteran population
Tyler D Aasen, David Wilhoite, Aynur Rahman, Kalpit Devani, Mark Young, James Swenson
Tyler D Aasen, David Wilhoite, Aynur Rahman, Kalpit Devani, Mark Young, Gastroenterology Section, East Tennessee State University Quillen College of Medicine, Johnson City, TN 37604, United States
James Swenson, Gastroenterology Section, Mountain Home Veterans Affairs Healthcare System, Mountain Home, TN 37684, United States
Author contributions: Aasen T designed the research; Aasen T, Wilhoite D, Rahman A, Devani K performed the data collection; Aasen T, Devani K performed the statistical analysis; Young M, Swenson J participated in project guidance and supervision; Aasen T wrote the paper.
Institutional review board statement: Approval was obtained for this study from the East Tennessee State University Institution Review Board.
Informed consent statement: All subjects of the study had informed consent addressed prior to study inclusion in compliance with East Tennessee State University IRB policy.
Conflict-of-interest statement: All authors have no conflicts of interest to report
Data sharing statement: The original anonymous dataset is available upon request at
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Tyler D Aasen, MD, Doctor, Gastroenterology Section, East Tennessee State University Quillen College of Medicine, 178 W Maple St., Johnson City, TN 37604, United States.
Telephone: +1-423-5348397 Fax: +1-423-4396386
Received: December 28, 2018
Peer-review started: December 29, 2018
First decision: January 12, 2019
Revised: January 20, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 16, 2019
Research background

Capsule endoscopy (CE) is frequently used in clinical practice to evaluate a wide spectrum of gastrointestinal symptoms and diseases. Capsule technology has advanced over time; however, it remains unclear if upgrades in capsule technology enhance clinically relevant findings during the procedure.

Research motivation

The Pillcam® SB3 capsule is a commonly used capsule that provides superior image quality and an adaptive frame rate advantage over the previous versions of the capsule the Pillcam® SB2. It has been proposed that these improvements may result in improved diagnostic yields of the CE study.

Research objectives

To assess clinically relevant findings of SB3 and SB2 capsules in a population of United States veterans.

Research methods

A retrospective analysis of 260 consecutive CE studies was performed including 130 SB3 and 130 SB2 capsule studies. The primary outcome measured was the detection of clinically relevant findings between SB3 and SB2 capsules. Whether the capsule study resulted in a change in clinical management was evaluated as a secondary measure.

Research results

The overall rate of clinically relevant finding was 48.9% in our study. No significant difference was observed in SB3 vs SB2 capsules for clinically relevant findings (46.2% vs 51.5%, P = 0.385) or change in clinical management (40.8% vs 50.0%, P = 0.135).

Research conclusions

Our study found no significant difference in clinically relevant findings between SB3 and SB2 capsules.

Research perspectives

Improvements in capsule technology should be critically analyzed to determine their impact on clinical practice. Further prospective research is warranted to confirm the results of our study.