Shi H, Chen SY, Lin K. Raman spectroscopy for early real-time endoscopic optical diagnosis based on biochemical changes during the carcinogenesis of Barrett’s esophagus. World J Gastrointest Endosc 2016; 8(5): 273-275 [PMID: 26981179 DOI: 10.4253/wjge.v8.i5.273]
Corresponding Author of This Article
Hong Shi, MD, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, No 420 FuMa Road, Fuzhou 350014, Fujian Province, China. endoshihong@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Mar 10, 2016; 8(5): 273-275 Published online Mar 10, 2016. doi: 10.4253/wjge.v8.i5.273
Raman spectroscopy for early real-time endoscopic optical diagnosis based on biochemical changes during the carcinogenesis of Barrett’s esophagus
Hong Shi, Su-Yu Chen, Kai Lin
Hong Shi, Su-Yu Chen, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian Province, China
Kai Lin, Department of General Surgery, Fuzhou Seventh Hospital, Fuzhou 350014, Fujian Province, China
Author contributions: Shi H and Chen SY were responsible for the study concept and design; all authors conducted endoscopic operations together; Chen SY and Lin K drafted the manuscript; Shi H revised and finalized the manuscript.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hong Shi, MD, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, No 420 FuMa Road, Fuzhou 350014, Fujian Province, China. endoshihong@hotmail.com
Telephone: +86-591-83660063 Fax: +86-591-83660063
Received: August 27, 2015 Peer-review started: October 1, 2015 First decision: November 30, 2015 Revised: December 16, 2015 Accepted: January 8, 2016 Article in press: January 11, 2016 Published online: March 10, 2016
Abstract
Raman spectroscopy is a spectroscopic technique based on the inelastic scattering of monochromatic light that represents the molecular composition of the interrogated volume to provide a direct molecular fingerprint. Several investigations have revealed that confocal Raman spectroscopy can differentiate non-dysplastic Barrett’s esophagus from esophageal high-grade dysplasia and adenocarcinoma with high sensitivity and specificity. An automated on-line Raman spectral diagnostic system has made it possible to use Raman spectroscopy to guide accurate target biopsy instead of multiple random forceps-biopsies, this novel system is expected to improve in vivo precancerous diagnosis and tissue characterization of Barrett’s esophagus.
Core tip: Raman spectroscopy is a very sensitive tool to detect subtle biochemical and molecular changes, which is crucial for differentiating nondysplastic from high-grade dysplastic Barrett’s esophagus. With an increased accuracy of updated algorithms and a real time automatic analysis system, Raman spectroscopy is expected to improve in vivo precancerous diagnosis and tissue characterization of Barrett’s esophagus.
