Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jan 16, 2015; 7(1): 73-76
Published online Jan 16, 2015. doi: 10.4253/wjge.v7.i1.73
Russell body duodenitis with immunoglobulin kappa light chain restriction
William R Munday, Lucy Harn Kapur, Mina Xu, Xuchen Zhang
William R Munday, Lucy Harn Kapur, Mina Xu, Xuchen Zhang, Department of Pathology, Yale University School of Medicine, New Haven, CT 06516, United States
Xuchen Zhang, Pathology and Laboratory Medicine Service, VA CT HealthCare System, West Haven, CT 06516, United States
Author contributions: Munday WR, Kapur LH and Zhang X contributed to the conception and design; Munday WR drafted and revised the manuscript; Zhang X and Xu M supervised and revised the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xuchen Zhang, MD, PhD, Department of Pathology, VA CT HealthCare System and Yale University School of Medicine, 950 Campbell Ave, West Haven, CT 06516, United States. xuchen.zhang@yale.edu
Telephone: +1-203-9325711 Fax: +1-203-9374704
Received: August 11, 2014
Peer-review started: August 13, 2014
First decision: September 16, 2014
Revised: October 17, 2014
Accepted: October 31, 2014
Article in press: November 3, 2014
Published online: January 16, 2015
Processing time: 156 Days and 17.4 Hours
Abstract

Russell bodies are eosinophilic intracytoplasmic globules which are likely the result of disturbed secretion of immunoglobulins that accumulate within the plasma cell. Russell body collections have been identified within the stomach, known as Russell body gastritis. Similar lesions within the duodenum are referred to as Russell body duodenitis, which is rare. Several Russell body gastritis case reports are associated with Helicobacter pylori. However, the etiology of Russell body duodenitis remains unclear. Here we report the first case of Russell body duodenitis with immunoglobulin light chain restriction in a background of peptic duodenitis.

Keywords: Russell body duodenitis; Russell bodies; Immunoglobulin

Core tip: Russell body duodenitis is rare and the etiology is unclear. We report a case of Russell body duodenitis with immunoglobulin light chain restriction in a background of peptic duodenitis.