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Li P, Ding RR, Liu J, Zhang MQ, Liu Y. Detachable over-the-scope clip for colon defects in the trans intestinal natural orifice transluminal endoscopic cholecystolithotomy: A case report. World J Gastrointest Endosc 2025; 17(8): 109399 [PMID: 40838163 DOI: 10.4253/wjge.v17.i8.109399]
World J Gastrointest Endosc. Aug 16, 2025; 17(8): 109399 Published online Aug 16, 2025. doi: 10.4253/wjge.v17.i8.109399
Detachable over-the-scope clip for colon defects in the trans intestinal natural orifice transluminal endoscopic cholecystolithotomy: A case report
Pei Li, Rong-Rong Ding, Jiang Liu, Ming-Qing Zhang, Yan Liu
Pei Li, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, Fujian Province 363000, Fujian Province, China
Rong-Rong Ding, Jiang Liu, Ming-Qing Zhang, Yan Liu, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, Zhangzhou 363000, Fujian Province, China
Co-first authors: Pei Li and Rong-Rong Ding.
Author contributions: Li P organized the case and wrote manuscript; Ding RR contributed to administered therapy for patient and wrote manuscript; Liu J contributed to supervised writing of manuscript; Zhang MQ contributed to performed surgical procedures for patient; Liu Y contributed to drafting the manuscript.
Supported by Natural Science Foundation of Fujian Province, China, No. 2021J01545.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yan Liu, Research Fellow, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, No. 269 Zhanghua Middle Road, Zhangzhou 363000, Fujian Province, China. 514461566@qq.com
Received: May 12, 2025 Revised: May 30, 2025 Accepted: June 27, 2025 Published online: August 16, 2025 Processing time: 97 Days and 18.3 Hours
Abstract
BACKGROUND
Secure transluminal closure remains a fundamental barrier to endoscopic surgery. It has been reported that through-the-scope clips were used to secure the incision of the gallbladder during natural orifice transluminal endoscopic cholecystolithotomy and were left in the body post-operation. The over-the-scope clip (OTSC) is favored for its rapid deployment and strong anchoring capabilities. Nevertheless, OTSCs are difficult to remove once implanted. The Senscure Biotechnology in China has developed a detachable over-the-scope clip (D-OTSC) for this purpose. Here, we utilized the D-OTSC to successfully close a full-thickness sigmoid defect exceeding 1 cm in diameter. Subsequently, the clip was completely removed postoperatively, yielding favorable clinical outcomes.
CASE SUMMARY
We present the case of a 51-year-old female patient who underwent natural orifice transluminal endoscopic cholecystolithotomy. The sigmoid incision was closed using a D-OTSC. Postoperative recovery was uneventful, with no abdominal infection or bleeding. The D-OTSC was subsequently removed via enteroscopy in the outpatient department one month later.
CONCLUSION
The utilization of D-OTSC presents a viable option for closing colonic mucosal incisions ranging from 1 cm to 2 cm.
Core Tip: In response to clinical requirements, ongoing efforts are being made to investigate the utilization of anastomotic or metal clips for the closure of various full-thickness defects in the mucosa of the digestive tract. Here, we present the case of a 51-year-old patient who underwent transintestinal natural orifice transluminal endoscopic cholecystolithotomy. The sigmoid incision was sealed using a detachable over-the-scope clip (D-OTSC), which was subsequently extracted during enteroscopy one month postoperatively. We believe that the D-OTSC is a viable option for closing colon defects ranging from 1 cm to 2 cm.
