Paramythiotis D, Tsavdaris D, Karlafti E. Reassessing cholecystectomy timing in gallstone-related acute cholangitis. World J Gastrointest Endosc 2025; 17(5): 106473 [DOI: 10.4253/wjge.v17.i5.106473]
Corresponding Author of This Article
Daniel Paramythiotis, MD, Full Professor, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, St. Kyriakidi 1, Thessaloniki 54636, Greece. danosprx@auth.gr
Research Domain of This Article
Surgery
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. May 16, 2025; 17(5): 106473 Published online May 16, 2025. doi: 10.4253/wjge.v17.i5.106473
Reassessing cholecystectomy timing in gallstone-related acute cholangitis
Daniel Paramythiotis, Dimitrios Tsavdaris, Eleni Karlafti
Daniel Paramythiotis, Dimitrios Tsavdaris, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece
Eleni Karlafti, Department of Emergency, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece
Author contributions: Paramythiotis D designed research; Tsavdaris D and Karlafti E performed research, analyzed data; Paramythiotis D wrote the letter; Tsavdaris D and Karlafti E revised the letter.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Daniel Paramythiotis, MD, Full Professor, 1st Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, St. Kyriakidi 1, Thessaloniki 54636, Greece. danosprx@auth.gr
Received: February 28, 2025 Revised: April 4, 2025 Accepted: April 22, 2025 Published online: May 16, 2025 Processing time: 73 Days and 10.6 Hours
Abstract
In this article, we discussed the article by Sohail et al, published in a recent issue of the World Journal of Gastrointestinal Endoscopy. This study highlights the benefits of performing cholecystectomy (CCY) during the same hospitalization for patients with acute cholangitis (AC) associated with gallstones. Specifically, same-admission CCY is associated with significantly lower 30-day readmission rates compared with interval CCY. Furthermore, it has been associated with reduced mortality rates and reduced recurrence of biliary symptoms. Despite these advantages, the procedure is chosen in only a minority of eligible patients. This gap between evidence and practice highlights the need for updated clinical guidelines and further research to optimize the timing of CCY in the management of AC.
Core Tip: Performing cholecystectomy during the same hospitalization for gallstone-related acute cholangitis significantly reduces 30-day readmission and mortality rates. Despite these benefits, the procedure is underutilized, highlighting the need for updated guidelines and further research to standardize early surgical intervention in appropriate patients.
