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World J Gastrointest Endosc. Feb 16, 2019; 11(2): 115-123
Published online Feb 16, 2019. doi: 10.4253/wjge.v11.i2.115
Spectrum of gastrointestinal involvement in Stevens - Johnson syndrome
Ashish Kumar Jha, Arya Suchismita, Rajeev Kumar Jha, Vikas Kumar Raj
Ashish Kumar Jha, Department of Gastroenterology, Indira Gandhi Institute of Medical Science, Sheikhpura, Patna 800014, India
Arya Suchismita, Department of Pediatrics, Indira Gandhi Institute of Medical Science, Sheikhpura, Patna 800014, India
Rajeev Kumar Jha, VMMC and Safdarjung Hospital, New Delhi 100001, India
Vikas Kumar Raj, Health Center, National Institute of Technology, Patna 800014, India
Author contributions: Jha AK and Suchismita A was involved in designing and writing the manuscript; Jha RK and Raj VK was responsible for a thorough literature search, Jha AK was involved in editing the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ashish Kumar Jha, MBBS, MD, Associate Professor, Department of Gastroenterology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna 800014, India. ashishjhabn@yahoo.co.in
Telephone: +91-612-2297631 Fax: +91-612-2297225
Received: August 17, 2018
Peer-review started: August 17, 2018
First decision: August 31, 2018
Revised: January 29, 2019
Accepted: February 13, 2019
Article in press: February 13, 2019
Published online: February 16, 2019
Abstract

Stevens - Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mucus membrane lesions usually involve the oral cavity, lips, bulbar conjunctiva and the anogenitalia. The oral/anal mucosa and liver are commonly involved in SJS or TEN. However, intestinal involvement is distinctly rare. We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN. This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN.

Keywords: Stevens - Johnson syndrome, Toxic epidermal necrolysis, Lyell’s syndrome, Gastrointestinal involvement, Colon, Ileum

Core tip: The oral/anal mucosa and liver are commonly involved in Stevens -Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). However, intestinal involvement is distinctly rare. We herein review the current literature regarding the gastrointestinal (GI) involvement in SJS or TEN. The extent of the GI involvement, clinical presentations, endoscopic and histopathological features, treatment options, and prognosis are described in this article.