Basic Study
Copyright ©The Author(s) 2016.
World J Hepatol. Jun 8, 2016; 8(16): 673-684
Published online Jun 8, 2016. doi: 10.4254/wjh.v8.i16.673
Table 1 Effect of Amylin liver nonalcoholic steatohepatitis model diet on metabolic parameters, non-alcoholic fatty liver disease activity score/fibrosis stage, body weight/composition and liver weight
Lean chow n = 9DIO-NASH n = 12ob/ob chow n = 8ob/ob NASH n = 10
Baseline plasma ALT (U/L)30.7 ± 0.8133.6 ± 16.3207.0 ± 58.7577.4 ± 43.4d,f
Terminal plasma ALT (U/L)31.5 ± 2.9126.1 ± 19.8249.7 ± 47.4670.0 ± 59.0d,f
Baseline plasma AST (U/L)46.5 ± 2.2134.8 ± 11.6b174.2 ± 41.1436.7 ± 36.8d,f
Terminal plasma AST (U/L)139.0 ± 28.2213.8 ± 31.6338.9 ± 87.7552.6 ± 49.5c,f
Baseline plasma TC (mmol/L)2.1 ± 0.16.8 ± 0.3b3.5 ± 0.210.4 ± 0.9d,f
Terminal plasma TC (mmol/L)2.3 ± 0.16.7 ± 0.4b4.4 ± 0.210.8 ± 0.6d,f
Baseline plasma TG (mmol/L)0.7 ± 0.10.9 ± 0.11.1 ± 0.20.8 ± 0.1
Terminal plasma TG (mmol/L)0.8 ± 0.11.0 ± 0.11.3 ± 0.10.7 ± 0.1d
OGTT-AUC1104 ± 49.71217 ± 39.91612 ± 173.41319 ± 61.4
Fasting blood glucose (mmol/L)7.3 ± 0.37.6 ± 0.28.1 ± 0.37.6 ± 0.3
Plasma insulin (pmol/L)30.6 ± 6.797.4 ± 18.31189 ± 94567.3 ± 123d,e
Baseline steatosis score (0-3)02.7 ± 0.3b1.8 ± 0.22.7 ± 0.3
Baseline fibrosis stage (0-4)01.8 ± 0.20.25 ± 0.22.7 ± 0.3d,f
Terminal NAFLD activity score (0-8)04.7 ± 0.4b2.4 ± 0.36.3 ± 0.2d
Terminal steatosis score (0-3)02.8 ± 0.1b2.1 ± 0.22.1 ± 0.2
Terminal inflammation score (0-3)01.4 ± 0.2b0.3 ± 0.22.4 ± 0.2d
Terminal ballooning degeneration score (0-2)00.4 ± 0.100.9 ± 0.1d
Terminal fibrosis stage (0-4)01.2 ± 0.2a0.1 ± 0.13.0 ± 0.2d,e
Terminal steatosis (% area)5.4 ± 0.533.9 ± 2.6b29.5 ± 2.341.2 ± 1.0c
Terminal fibrosis (% area)0.3 ± 0.11.1 ± 0.21.2 ± 0.24.9 ± 0.7d,e
Terminal BW (g)28.0 ± 0.339.1 ± 1.159 ± 1.154.8 ± 0.8e
Terminal lean tissue mass (g)14.6 ± 0.818.8 ± 0.5b19.9 ± 0.917.3 ± 0.4c
Terminal lean tissue mass (% of BW)49.6 ± 2.647.7 ± 1.533.6 ± 1.131.9 ± 0.6f
Terminal fat tissue mass (g)1.5 ± 0.18.1 ± 0.7b25.1 ± 0.722.5 ± 0.5c,f
Terminal fat tissue mass (% of BW)5.1 ± 0.520.0 ± 1.3b42.3 ± 0.841.5 ± 0.5f
Liver weight (g)1.1 ± 0.12.5 ± 0.3b2.9 ± 0.25.4 ± 0.2d,f
Liver weight (% of BW)3.9 ± 0.36.3 ± 0.6b4.9 ± 0.39.9 ± 0.3d,f