Strategies to improve outcome of patients with hepatocellular carcinoma receiving a liver transplantation

Table 1 Summary of the most relevant criteria used to select candidates with hepatocellular carcinoma for liver transplantation

Ref.	Name of criteria	No. of nodules	Diameter	Tumour different	PIVKA-II	Prospective validation	n	Outcomes within Milan criteria	Outcomes within proposed criteria	P
Mazzaferro et al[13]	Milan	1 or ≤ 3	≤ 5 cm or ≤ 3 cm each	-	-	+	48	4-yr survival rate 75% 4-yr recurrence free survival rate 83%	NA
Mazzaferro et al[16]	Up-to-seven	TTN + DLN ≤ 7		-	-	+[139-141]	1556	5-yr survival rate 73.3%	5-yr survival rate 71.2%	> 0.05
Yao et al[18]	UCSF criteria	1 or ≤ 3	≤ 6.5 cm or ≤ 4.5 cm the largest one but with a TTD ≤ 8 cm	-	-	+[21]	70	5-yr survival rate 72.4%	5-yr survival rate 75.2%	0.87
Herrero et al[23]	Universidad de Navarra criteria	1 or 2-3	≤ 6 cm or ≤ 5 cm	-	-	-	47	Not reported	5-yr survival rate 79% 3-yr recurrence free survival rate 70%	-
Lee et al[32]	Asan criteria	≤ 6	≤ 5 cm	-	-	-	221	5-yr survival rate 76% 3-yr recurrence rate 13.6%	5-yr survival rate 81.6% 3-yr recurrence rate 9.1%	0.334 0.554
DuBay et al[27]	Toronto criteria	No	No	+	-	-	294	5-yr overall survival rate 72% 5-yr disease free survival rate 70%	5-yr overall survival rate 70% 5-yr disease free survival 66%	0.63 0.25
Ito et al[24]	Kyoto criteria	≤ 10	≤ 5 cm	-	+	-	125	Not reported	5-yr survival 86.7% 5-yr recurrence 4.9%	-

TTN: Total tumor nodules; DLN: Diameter of the largest nodule; TTD: Total tumor diameter; NA: Not applicable.