Published online Apr 8, 2015. doi: 10.4254/wjh.v7.i4.649
Peer-review started: August 25, 2014
First decision: November 27, 2014
Revised: December 15, 2014
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: April 8, 2015
Core tip: Liver transplantation is the only therapeutic option which allows to treat both, the hepatocellular carcinoma and the underlying liver disease. However, tumour recurrence rates are 15%-20% with a very poor prognosis. Strategies to minimize tumour recurrence and thus to improve outcome are focused in a careful selection of candidates for liver transplantation, an optimized management within waiting list and a tailored immunosuppression. The available scientific evidence supporting these strategies is reviewed, and future directions are provided for novel research approaches, which may contribute to the final target: to cure more patients with hepatocellular carcinoma with an improved long term outcome.