Copyright ©The Author(s) 2015.
World J Hepatol. Mar 27, 2015; 7(3): 607-615
Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
Table 1 Scoring system of liver fibrosis in liver biopsy
METAVIR score0112344
No fibrosisPortal fibrosis without septaPortal fibrosis without septaSeptal fibrosis (portal-portal)Septal fibrosis (portal-central)CirrhosisCirrhosis
Ishak score123456
No fibrosisSome portal tract fibrotic ± short fibrous septaMost portal tract fibrotic ± short fibrous septaPortal tract fibrotic with occasional portal to portal bridgingPortal tract fibrotic with marked portal to portal and portal to central bridgingMarked portal to portal and/or portal to central with occasional nodulesCirrhosis
Table 2 Pathologic, hemodynamic, and clinical stage of liver fibrosis
METAVIR scoreF0-F3F4F4F4F4
HVPG (mmHg)> 6> 10> 12> 16 > 20
Clinical classStage 1Stage 2Stage 3Stage 4-5
VaricesVarices AscitesVariceal bleeding Ascites Other complications
1-yr mortality (%)1310-3060-100