Copyright ©The Author(s) 2015.
World J Hepatol. Mar 27, 2015; 7(3): 315-326
Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.315
Table 1 Role of adipocytokines in non-alcoholic fatty liver disease and psoriasis
Anti-inflammatoryAdiponectin↓ Promotes anti-inflammatory cytokines↓ Increase insulin-sensitivity
Pro-inflammatoryIL-6 TNF-α↑ Keratinocyte proliferation ↑ (1) Keratinocyte proliferation; (2) Angiogenesis; and (3) Promotes expression of adhesion molecules; and (4) Increase pro-inflammatory cytokines↑ Contributes to insulin-resistance ↑ Contributes to insulin-resistance; Increase hepatic fibrogenesis
Leptin↑ (1) Keratinocyte proliferation; (2) Promotes Th1 responses; and (3) Angiogenesis↑ (1) Leptin-resistance; and (2) Contributes to hepatic fibrogenesis
Resistin↑ Increase pro-inflammatory cytokines↑ (1) Contributes to insulin-resistance; and (2) Controversial data on NAFLD
VisfatinNot altered in early stage; Protection toward liver injury (?); Negatively correlated to TNF-α