Case Report
Copyright ©The Author(s) 2015.
World J Hepatol. Sep 8, 2015; 7(19): 2229-2236
Published online Sep 8, 2015. doi: 10.4254/wjh.v7.i19.2229
Table 1 Additional risk factors for thrombosis[6]
Age (> 55 in men, > 65 in women)
Risk factors for CVD
Diabetes mellitus
Elevated LDL or low HDL - cholesterol
Family history of premature CVD
BMI ≥ 30 kg/m2
Estimated GFR < 60 mL/min
Inherited thrombophilias
Oral contraceptives
Nephrotic syndrome
Table 2 Summary of the abdominal manifestations associated with the antiphospholipid syndrome[12]
Abdominal organManifestations
LiverBudd-Chiari syndrome:
Hepatic veno-occlusive disease and occlusion of small hepatic veins
Nodular regenerative hyperplasia
Hepatic infarction
Portal hypertension
Autoimmune hepatitis
Biliary cirrhosis
Liver transplantation
IntestineMesenteric ischemia (acute-chronic)[13,14]
Peptic ulcer disease[15,16]
Bowel ischemia and perforation[17]
High prevalence of aPL but no increased vascular thromboses in inflammatory bowel disease
SpleenSplenic infarction
Autosplenectomy or functional asplenia
PancreasAcute pancreatitis
Table 3 Patient S's inherent thrombophilia markers
FV Leiden-/-
G20210A in prothrombin gene+/-
C10034T in γ-phibrinogen gene-/-
Methylene tetrahydrofolate reductase 677TT polymorphism+/-
4G/5G plasminogen activator inhibitor 1+/+
G29926C in THBS gene (thrombospondine-4 gene)-/-
G10976A in VII factor gene-/-
С807Т in GpIa gene-/-
Т1565С in GpIIIa gene-/-
CYP2C9*2 ( cytochrome Р450 gene)-/-
CYP2C9*3 (cytochrome Р450 gene)-/-
G1639A in VKORC 1 gene (vitamin K hypoxide reductase gene)-/-
I/D-polymorphism in ACE gene (anghiotensin-converting ferment gene)-/-