Published online Sep 8, 2015. doi: 10.4254/wjh.v7.i19.2229
Peer-review started: February 26, 2015
First decision: June 18, 2015
Revised: August 10, 2015
Accepted: August 20, 2015
Article in press: August 21, 2015
Published online: September 8, 2015
The antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced to a variety of phospholipids determinants of cell membranes or phospholipid binding proteins. There are few reports about association between antiphospholipid antibodies and development of Budd-Chiari syndrome (BCS). We report the case of BCS development in young Russian male with primary APS. The patient underwent orthotopic liver transplantation on August 26, 2012. At present time his state is good, the blood flow in the liver restored and its function is not impaired. We report about the first time the successful use of dabigatran etexilate for prolonged anticoagulation therapy in APS patient with BCS. In addition patient is managed with immunosuppressive drugs.
Core tip: Budd-Chiari syndrome (BCS) is rare disease with a potentially dismal outcome if not treated optimally. In manuscript is reported the case report of the BCS development in young Russian male with primary antiphospholipid syndrome (APS), who was underwent orthotopic liver transplantation and now is managed with immunosupressive drugs and with prolonged anticoagulation. For the first time, it is reported the successful use of dabigatran etexilate for prolongation anticoagulation therapy in primary APS patient with BCS.