Management of hepatocellular carcinoma in the elderly

Table 1 Outcome of elderly and younger patients with hepatocellular carcinoma undergoing resection

Ref.	Age limits (yr)	O/Y	Survival (%)			DFS
			1 yr	3 yr	5 yr	1 yr	3 yr	5 yr
Yeh et al[38]	70	30/398	85	64	39	NA	NA	29
			NA	46	NA	NA	NA	27
Zhou et al[39]	70	55/124	89	57	50	74	31	30
			80	49	38	63	34	16
Kondo et al[34]	70	109/210	78	45	42	NA	NA	NA
			79	52	47
Kaibori et al[50]	70	155/333	NA	70	55	NA	30	21
			NA	70	57	NA	38	23
Oishi et al[25]	75	62/504	NA	77	58	NA	43	30
			NA	81	64	NA	46	28
Huang et al[35]	70	67/268	83	55	43b	69	58	47
			72	40	31	65	41	36
Poon et al[23]	70	31/299	79	58	29	57	27	27
			75	51	40	54	38	24
Tsujita et al[47]	75	23/77	95	70	NA	60	38	NA
			96	83	NA	61	35	NA
Su et al[36]	55	700/374	87	66	51	NA	NA	NA
			82	67	59	NA	NA	NA
Nishikawa et al[51]	75	92/206	90	73	43	66	39	26
			91	78	64	66	39	22

^bP < 0.01. Data on younger patients are reported in italics. Only articles reporting on either survival and disease free survival (DFS) were considered. O/Y: Old/young.

Table 2 Outcome of elderly and younger patients with hepatocellular carcinoma undergoing radiofrequency ablation

Ref.	Age limits (yr)	O/Y	Survival (%)			DFS
			1 yr	3 yr	5 yr	1 yr	3 yr	5 yr
Tateishi et al[62]	68	159/160	NA	76	NA	NA	NA	NA
			NA	79	NA	NA	NA	NA
Mirici-Cappa et al[41]	70	159/230	90.1	53.4	29	NA	NA	NA
			89.9	52.9	35.1	NA	NA	NA
Nishikawa et al[31]	75	130/238	90	64.1	44.8	66.9	21.3	19
			97.6	83.7	64b	80.5	40	19.5b
Takahashi et al[32]	75	107/354	NA	82	61	NA	492	562
			NA	80	63	NA	492	562
Kao et al[33]	65	158/100	NA	NA	81.3	NA	NA	NA
			NA	NA	65.4	NA	NA	NA
Hiraoka et al[63]	75	63/143	93	83	501	NA	NA	NA
			93	78	58	NA	NA	NA

Data on younger patients are reported in italics. Only articles reporting on either survival and disease free survival (DFS) or overall recurrence² were considered.

^bP = 0.001;

¹Not significant. O/Y: Old/young; NA: Not available.