Case Control Study
Copyright ©The Author(s) 2021.
World J Hepatol. Dec 27, 2021; 13(12): 2071-2080
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.2071
Table 1 Patients’ demographics and clinical characteristics
Control group (n = 17)Liver cirrhosis
P value
Pugh-Child A + B (n = 37)
Pugh-Child C (n = 32)
Age (yr)43.7 ± 14.655.7 ± 12.155.9 ± 10.20.021
Percentage of males (%)64.3%73%72.7%0.52
Body weight (kg)67.6 ± 8.973 ± 11.475.5 ± 12.80.17
Height (cm)173 ± 5.9174 ± 8173 ± 7.60.64
Duration of alcohol abuse (yr)-15.7 ± 8.218.7 ± 8.30.98
Oesophageal varices (%)-32.4%81.8%< 0.0001
Encephalopathy (%)-32.4%83.9%< 0.0001
Ascites (%)-40.5%90.9%< 0.0001
Total bilirubin (mg/dL)0.6 ± 0.34.6 ± 6.910.5 ± 9.2< 0.0001
INR-1.36 ± 0.351.95 ± 0.56< 0.0001
Albumin (g/dL)-3.1±0.82.4±0.40.0002
Total protein (g/dL)6.3 ± 0.36.4 ± 15.9 ± 0.90.16
Alanine aminotransferase (U/L)17.9 ± 665.3 ± 139.950.6 ± 87.30.018
Aspartate aminotransferase (U/l)18.3 ± 7128.1 ± 173.5120 ± 164.7< 0.0001
Platelets (G/L)231.4 ± 29.8173 ± 105.4127.8 ± 72.30.0004
Mean corpuscular volume (fL)84.8 ± 3.591.2 ± 9.195.5 ± 90.0002
Urea (mg/dL)-27.5 ± 16.158.2 ± 43.70.065
Sodium (mmol/l)140 ± 3.3133.8 ± 5131.9 ± 6.7< 0.0001
Potassium (mmol/L)4.4 ± 0.43.8 ± 0.73.9 ± 0.80.019
C-reactive protein (mg/L)2.5 ± 2.319.8 ± 2132.7 ± 27.8< 0.0001
Angiotensinogen (ng/mL)1006.91 ± 610.491117.04 ± 873.691468.7 ± 817.330.22
Table 2 Levels of selected biochemical parameters according to the stage of liver cirrhosis
Control group Liver cirrhosis
P value
Pugh-Child A + B
Pugh-Child C
LECT2 (ng/mL)18.99 ± 5.3611.06 ± 6.478.06 ± 5.74< 0.0001
FGF-1 (pg/mL)37.94 ± 40.4144.77 ± 14.42164.52 ± 169.460.01
FGF-21 (pg/mL)13.52 ± 7.5144.27 ± 64.1945.4 ± 51.690.008
Table 3 Correlations between leukocyte cell-derived chemotaxin-2 and other clinical and laboratory parameters (only those statistically significant were included)
Pair of variablesCorrelation coefficient
R
P value
LECT2Age-0.290.048
Total bilirubin-0.59< 0.0001
Platelets0.340.02
Alanine transaminase-0.430.003
C-reactive protein-0.40.008
Angiotensinogen-0.51< 0.0001
FGF-1-0.380.004
FGF-21-0.390.004
Table 4 Independent factors associated with leukocyte cell-derived chemotaxin-2 concentration (multiple regression)
Effect
B*
SE with B*
B
SE with B
P value
Constant30.643.68< 0.0001
Angiotensinogen-0.4230.114-0.0040.0010.001
Alanine aminotransferase-0.3410.115-0.020.0050.005
Total bilirubin-0.2790.108-0.250.0990.014
Age-0.2750.109-0.160.0640.016