Case Control Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2021; 13(12): 2071-2080
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.2071
Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis
Jarosław Jerzy Sak, Andrzej Prystupa, Paweł Kiciński, Dorota Luchowska-Kocot, Ewa Kurys-Denis, Hanna Bis-Wencel
Jarosław Jerzy Sak, Chair and Department of Humanities and Social Medicine, Medical University of Lublin, Lublin 20-093, Poland
Andrzej Prystupa, Department of Internal Medicine, Medical University of Lublin, Lublin 20-081, Poland
Paweł Kiciński, Department of Experimental Hematooncology, Medical University of Lublin, Lublin 20-080, Poland
Dorota Luchowska-Kocot, Department of Medical Chemistry, Medical University of Lublin, Lublin 20-093, Poland
Ewa Kurys-Denis, The Second Department of Radiology, Medical University of Lublin, Lublin 20-081, Poland
Hanna Bis-Wencel, Department of Microbiology and Reproductive Biology, University of Life Sciences in Lublin, Lublin 20-950, Poland
Author contributions: Sak JJ and Prystupa A were involved in the conception of the study, data collection and analysis, drafting and revision of the manuscript; Kiciński P and Luchowska-Kocot D were involved in the data collection and analysis; Kurys-Denis E was involved in the drafting and revision of the manuscript; Bis-Wencel H contributed to the data collection and revision of the manuscript.
Supported by the Grant from the Medical University of Lublin, No. DS 507/2013–2015.
Institutional review board statement: The study protocol was approved by the Bioethics Committee at Medical University of Lublin, Poland.
Informed consent statement: All patients gave their written informed consent for participation in the study.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jarosław Jerzy Sak, MD, PhD, Academic Research, Additional Professor, Director, Chair and Department of Humanities and Social Medicine, Medical University of Lublin, ul. Chodźki 7 (Collegium Academicum), Lublin 20-093, Poland.
Received: January 4, 2021
Peer-review started: January 4, 2021
First decision: July 8, 2021
Revised: July 22, 2021
Accepted: November 24, 2021
Article in press: November 24, 2021
Published online: December 27, 2021
Research background

Leukocyte cell-derived chemotaxin-2 (LECT2) has been widely studied to determine its usefulness for monitoring the course of non-alcoholic fatty liver disease but not for alcoholic liver cirrhosis (ALC).

Research motivation

The aim of our study was to assess and discuss LECT2’s possible wider use in the diagnosis of ALC.

Research objectives

The purpose of this study was to determine the concentration of LECT2 in the blood serum of patients in accordance with progressive stages of ALC and its relation to fibroblast growth factor 1 (FGF-1) and FGF-21.

Research methods

A study was conducted with an ALC group and a control group with no ALC. The extent of ALC was evaluated according to Pugh-Child criteria (the Pugh-Child score). LECT2, FGF-1, and FGF-21 were determined using enzyme-linked immunosorbent assay kits.

Research results

Our study showed strong correlations between LECT2 and cirrhosis progression. LECT2 levels correlated inversely with FGF-1 and FGF-21.

Research conclusions

LECT2 may be used for the non-invasive diagnosis of alcohol-induced liver cirrhosis.

Research perspectives

Further prospective studies should be conducted to explore whether the inverse correlation of LECT2 and FGF-21 is specific to ALD.