Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients

Table 2 Changes in anthropometric measurements and biochemistry between the patients’ first and second liver biopsy

	Pre bariatric surgery	Post bariatric surgery	P value
Weight (kg)	130.8 ± 20.1	82.3 ± 13.7	< 0.001
BMI (kg/m2)	49.3 ± 4.8	30.9 ± 4.3	< 0.001
% excess weight loss		72.1 ± 6.6
Waist (cm)	137.1 ± 12.6	97.3 ± 11.0	< 0.001
Diabetic (%)	12 (46.1)	6 (23)	0.14
Hypertensive (%)	17 (65.4)	7 (26.9)	0.012
Metabolic syndrome	15 (57.7)	2 (7.7)	< 0.001
Cholesterol (mmol/L)	5.44 ± 1.00	4.29 ± 0.85	< 0.001
HDL-C (mmol/L)	1.24 ± 0.21	1.40 ± 0.19	0.005
LDL-C (mmol/L)	3.47 ± 0.76	2.46 ± 0.75	< 0.001
Triglycerides (mmol/L)	1.60 ± 0.63	0.93 ± 0.29	< 0.001
AST (μkat/L)	0.35 ± 0.09	0.36 ± 0.17	0.862
ALT (μkat/L)	0.49 ± 0.20	0.37 ± 0.31	0.143
GGT (U/L)	40.2 ± 17.4	19.2 ± 12.8	< 0.001
Fasting glucose (mmol/L)	6.46 ± 2.3	4.96 ± 0.55	0.001
Insulin (pmol/L)	235.2 ± 7.2	56.1 ± 7.2	0.006
Insulin resistance (HOMA)	9.99 ± 13.3	1.8 ± 1.4	0.006

BMI: Body mass index; HDL-C: High density lipoprotein cholesterol; LDL-C: Low density lipoprotein cholesterol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; HOMA: Homeostatic model assessment method.